HitPredict

Interactor 1: SHIP2 (O15357)
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2)
Gene: INPPL1

Interactor 2: K22E (P35908)
Keratin, type II cytoskeletal 2 epidermal (Cytokeratin-2e) (CK-2e) (Epithelial keratin-2e) (Keratin-2 epidermis) (Keratin-2e) (K2e) (Type-II keratin Kb2)
Gene: KRT2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	19380743
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1258 Hs			1 639
+	Hs
		176339 SHIP2_HUMAN (1-1258): 0: 968: 100.00		K2C1_HUMAN (143-509): 1.63e-112: 353: 71.94
+	Hs
		176466 SHIP2_HUMAN (1-1258): 0: 968: 100.00		K2C73_HUMAN (1-598): 8.9e-92: 296: 51.00
+	Hs
		176371 SHIP2_HUMAN (1-1258): 0: 968: 100.00		K2C5_HUMAN (1-494): 7.49e-82: 271: 61.48
+	Hs
		176338 SHIP2_HUMAN (1-1258): 0: 968: 100.00		K2C6B_HUMAN (5-510): 8.35e-82: 270: 61.22
+	Hs
		176407 SHIP2_HUMAN (1-1258): 0: 968: 100.00		K2C6C_HUMAN (5-510): 2.02e-81: 269: 61.61
+	Hs
		176454 SHIP2_HUMAN (1-1258): 0: 968: 100.00		K2C79_HUMAN (32-568): 4.69e-80: 264: 55.35
+	Hs
		176364 SHIP2_HUMAN (1-1258): 0: 968: 100.00		K2C3_HUMAN (27-494): 2.18e-66: 230: 64.32
+	Hs
		203197 SYNJ1_HUMAN (186-1224): 0: 604: 16.35		K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33