HitPredict

Interactor 1: HDAC3 (O15379)
Histone deacetylase 3 (HD3) (EC 3.5.1.98) (Protein deacetylase HDAC3) (EC 3.5.1.-) (Protein deacylase HDAC3) (EC 3.5.1.-) (RPD3-2) (SMAP45)
Gene: HDAC3

Interactor 2: CSK21 (P68400)
Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1)
Gene: CSNK2A1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	15805470, 21624135
Identification Methods	enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 428 Hs			1 391
+	Hs
		934151 HDAC1_HUMAN (3-385): 0: 588: 62.92		CSK21_HUMAN (1-391): 2.89e-136: 396: 100.00
+	Hs
		1038545 HDAC1_HUMAN (3-385): 0: 588: 62.92		CSK23_HUMAN (1-391): 5.89e-133: 388: 98.47
+	Hs
		934359 HDAC2_HUMAN (3-422): 0: 580: 58.63		CSK21_HUMAN (1-391): 2.89e-136: 396: 100.00
+	Hs
		1243542 HDAC2_HUMAN (3-422): 0: 580: 58.63		CSK23_HUMAN (1-391): 5.89e-133: 388: 98.47
+	Hs
		177190 HDAC3_HUMAN (1-428): 0: 600: 100.00		CSK22_HUMAN (1-334): 4.14e-119: 351: 85.08
+	Hs
		586732 HDAC1_HUMAN (3-385): 0: 588: 62.92		CSK22_HUMAN (1-334): 4.14e-119: 351: 85.08
+	Hs
		586893 HDAC2_HUMAN (3-422): 0: 580: 58.63		CSK22_HUMAN (1-334): 4.14e-119: 351: 85.08
+	Sc
		549985 RPD3_YEAST (3-414): 0: 543: 57.07		CSK21_YEAST (1-329): 6.88e-113: 336: 54.32
+	Sp
		140599 PHD1_SCHPO (3-407): 0: 519: 56.27		CSK2A_SCHPO (2-325): 1.07e-118: 349: 66.05
+	Sc
		691003 RPD3_YEAST (3-414): 0: 543: 57.07		HOG1_YEAST (39-323): 2.35e-40: 150: 33.56
+	Hs
		587040 HDAC6_HUMAN (5-320): 3.49e-103: 333: 23.24		CSK22_HUMAN (1-334): 4.14e-119: 351: 85.08
+	Hs
		836055 HDAC6_HUMAN (5-320): 3.49e-103: 333: 23.24		GSK3B_HUMAN (39-389): 1.2e-112: 337: 29.12