HitPredict

Interactor 1: HDAC3 (O15379)
Histone deacetylase 3 (HD3) (EC 3.5.1.98) (Protein deacetylase HDAC3) (EC 3.5.1.-) (Protein deacylase HDAC3) (EC 3.5.1.-) (RPD3-2) (SMAP45)
Gene: HDAC3

Interactor 2: GTF2I (P78347)
General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein)
Gene: GTF2I

Species: Homo sapiens

Source: dip

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.717

Property	Details
Experiments	12393887, 12239342, 17970752, 16943425, 21549311
Identification Methods	affinity chromatography technology, pull down, coimmunoprecipitation, experimental interaction detection
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0006366 - transcription by RNA polymerase II GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 428 Hs			1 998
+	Hs
		942155 HDAC1_HUMAN (3-385): 0: 588: 62.92		GTF2I_HUMAN (1-998): 0: 1555: 100.00
+	Hs
		942220 HDAC2_HUMAN (3-422): 0: 580: 58.63		GTF2I_HUMAN (1-998): 0: 1555: 100.00
+	Hs
		177398 HDAC3_HUMAN (1-428): 0: 600: 100.00		GT2D1_HUMAN (571-975): 2.18e-31: 134: 23.30