HitPredict

Interactor 1: NVL (O15381)
Nuclear valosin-containing protein-like (NVLp) (Nuclear VCP-like protein)
Gene: NVL

Interactor 2: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016020 - membrane
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 856 Hs			1 768
+	Hs
		874907 TERA_HUMAN (67-485): 7.4e-92: 309: 24.71		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042056 AFG2A_HUMAN (67-492): 1.93e-84: 291: 23.49		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042444 AFG2B_HUMAN (570-842): 1.73e-59: 218: 39.49		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		874908 TERA_HUMAN (67-485): 7.4e-92: 309: 24.71		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		874909 TERA_HUMAN (67-485): 7.4e-92: 309: 24.71		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		1040745 PEX6_HUMAN (520-842): 2.02e-25: 115: 22.39		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		218008 PEX1_HUMAN (456-842): 4.04e-19: 95.1: 15.05		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		874905 TERA_HUMAN (67-485): 7.4e-92: 309: 24.71		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		874906 TERA_HUMAN (67-485): 7.4e-92: 309: 24.71		CUL2_HUMAN (30-768): 0: 672: 26.17
+	Dm
		1097193 TERA_DROME (67-544): 6.17e-93: 311: 23.35		CUL1_DROME (29-768): 0: 669: 27.49
+	Hs
		875192 TERA_HUMAN (67-485): 7.4e-92: 309: 24.71		CUL5_HUMAN (25-768): 0: 597: 23.77
+	Sc
		636771 CDC48_YEAST (67-552): 8.38e-92: 309: 22.83		CDC53_YEAST (30-768): 0: 573: 22.08