HitPredict

Interactor 1: SIGL5 (O15389)
Sialic acid-binding Ig-like lectin 5 (Siglec-5) (CD33 antigen-like 2) (Obesity-binding protein 2) (OB-BP2) (OB-binding protein 2) (CD antigen CD170)
Gene: SIGLEC5

Interactor 2: TLR3 (O15455)
Toll-like receptor 3 (CD antigen CD283)
Gene: TLR3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	25187624
Identification Methods	enzyme linked immunosorbent assay
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ig_3~LRR_8, LRR_8~V-set
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 551 Hs			1 904
+	Hs
		177607 SIGL5_HUMAN (1-551): 1.91e-116: 357: 100.00		TLR9_HUMAN (1-902): 1.39e-102: 344: 21.01
+	Mm
		885976 Q3Y597_MOUSE (19-245): 4.65e-97: 299: 48.25		TLR8_MOUSE (23-901): 7.9e-99: 334: 21.28
+	Mm
		1113884 Q3Y597_MOUSE (19-245): 4.65e-97: 299: 48.25		TLR2_MOUSE (134-899): 4.2e-95: 318: 20.34
+	Mm
		1265316 SIGL5_MOUSE (1-551): 5.75e-83: 271: 43.77		TLR5_MOUSE (5-900): 2.42e-95: 320: 19.81
+	Mm
		1265317 SIGL5_MOUSE (1-551): 5.75e-83: 271: 43.77		TLR4_MOUSE (46-897): 7.68e-95: 319: 19.70
+	Mm
		1265318 SIGL5_MOUSE (1-551): 5.75e-83: 271: 43.77		TLR2_MOUSE (134-899): 4.2e-95: 318: 20.34
+	Hs
		177592 SIGL5_HUMAN (1-551): 1.91e-116: 357: 100.00		TLR2_HUMAN (1-542): 1.05e-37: 153: 16.64
+	Hs
		177591 SIGL5_HUMAN (1-551): 1.91e-116: 357: 100.00		TLR5_HUMAN (51-411): 6.87e-35: 145: 22.28
+	Hs
		177608 SIGL5_HUMAN (1-551): 1.91e-116: 357: 100.00		TLR8_HUMAN (366-659): 2e-17: 89.8: 20.00
+	Hs
		120112 SIGL5_HUMAN (1-551): 1.91e-116: 357: 100.00		TLR4_HUMAN (5-532): 2.57e-17: 89.1: 18.00
+	Mm
		1113883 Q3Y597_MOUSE (19-245): 4.65e-97: 299: 48.25		TLR6_MOUSE (6-576): 1.96e-33: 140: 17.99
+	Hs
		177610 SIGL5_HUMAN (1-551): 1.91e-116: 357: 100.00		TLR7_HUMAN (32-159): 1.69e-14: 80.2: 27.61
+	Mm
		1113882 Q3Y597_MOUSE (19-245): 4.65e-97: 299: 48.25		TLR1_MOUSE (39-575): 6.2e-31: 132: 16.45
+	Mm
		292557 ROBO1_MOUSE (4-547): 3.06e-83: 285: 15.07		SLIT3_MOUSE (20-160): 2.67e-33: 141: 28.37
+	Hs
		177614 SIGL5_HUMAN (1-551): 1.91e-116: 357: 100.00		TLR6_HUMAN (31-572): 3.74e-10: 66: 15.78
+	Hs
		177605 SIGL5_HUMAN (1-551): 1.91e-116: 357: 100.00		TLR10_HUMAN (31-503): 5.55e-10: 65.2: 15.81
+	Hs
		177599 SIGL5_HUMAN (1-551): 1.91e-116: 357: 100.00		TLR1_HUMAN (31-517): 1.05e-09: 64.5: 13.95
+	Mm
		1265315 SIGL5_MOUSE (1-551): 5.75e-83: 271: 43.77		TLR1_MOUSE (39-575): 6.2e-31: 132: 16.45
+	Mm
		885974 Q3Y597_MOUSE (19-245): 4.65e-97: 299: 48.25		TLR7_MOUSE (50-260): 5.38e-20: 97.9: 21.92
+	Dm
		621591 Q9GPP6_DROME (1-543): 3.08e-67: 238: 13.61		SLIT_DROME (366-574): 6.12e-23: 107: 24.40