HitPredict

Interactor 1: SIGL5 (O15389)
Sialic acid-binding Ig-like lectin 5 (Siglec-5) (CD33 antigen-like 2) (Obesity-binding protein 2) (OB-BP2) (OB-binding protein 2) (CD antigen CD170)
Gene: SIGLEC5

Interactor 2: PTN11 (Q06124)
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Gene: PTPN11

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.50	0.609

Property	Details
Experiments	28514442, 33961781, 19596804
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 551 Hs			1 593
+	Hs
		177594 SIGL5_HUMAN (1-551): 1.91e-116: 357: 100.00		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Hs
		986018 SIG11_HUMAN (10-550): 1.07e-50: 186: 34.46		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		985950 PTK7_HUMAN (16-532): 4.11e-48: 181: 13.70		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		986013 SIG10_HUMAN (10-550): 1.03e-48: 181: 30.40		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Mm
		719313 SIG10_MOUSE (10-545): 5.72e-46: 173: 28.78		PTN11_MOUSE (1-593): 0: 580: 99.49
+	Hs
		986062 SIGL9_HUMAN (181-551): 5.6e-37: 144: 19.35		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		986060 SIGL7_HUMAN (181-551): 2.78e-34: 137: 20.60		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		665942 SIG11_HUMAN (10-550): 1.07e-50: 186: 34.46		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Hs
		665883 PTK7_HUMAN (16-532): 4.11e-48: 181: 13.70		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Hs
		665940 SIG10_HUMAN (10-550): 1.03e-48: 181: 30.40		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Mm
		665976 CD22_MOUSE (30-547): 9.12e-47: 177: 17.09		PTN6_MOUSE (6-583): 0: 530: 55.94
+	Hs
		532367 CEAM1_HUMAN (56-548): 1.84e-27: 117: 20.65		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		589567 CD33_HUMAN (251-549): 3.29e-28: 117: 23.74		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		665971 SIGL9_HUMAN (181-551): 5.6e-37: 144: 19.35		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Hs
		581691 VCAM1_HUMAN (94-428): 7.72e-19: 92.2: 18.70		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		665970 SIGL7_HUMAN (181-551): 2.78e-34: 137: 20.60		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Hs
		532361 CEAM1_HUMAN (56-548): 1.84e-27: 117: 20.65		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Hs
		589559 CD33_HUMAN (251-549): 3.29e-28: 117: 23.74		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Hs
		581462 VCAM1_HUMAN (94-428): 7.72e-19: 92.2: 18.70		PTN4_HUMAN (143-535): 1.5e-113: 362: 30.46
+	Hs
		1069952 PXDN_HUMAN (167-534): 2.97e-44: 170: 11.65		PTPRK_HUMAN (36-524): 5.17e-72: 254: 18.94