HitPredict

Interactor 1: SIGL5 (O15389)
Sialic acid-binding Ig-like lectin 5 (Siglec-5) (CD33 antigen-like 2) (Obesity-binding protein 2) (OB-BP2) (OB-binding protein 2) (CD antigen CD170)
Gene: SIGLEC5

Interactor 2: TLR1 (Q15399)
Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281)
Gene: TLR1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	25187624
Identification Methods	enzyme linked immunosorbent assay
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ig_3~LRR_8, LRR_8~V-set
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 551 Hs			1 786
+	Hs
		177614 SIGL5_HUMAN (1-551): 1.91e-116: 357: 100.00		TLR6_HUMAN (5-781): 8.07e-124: 392: 68.86
+	Hs
		177605 SIGL5_HUMAN (1-551): 1.91e-116: 357: 100.00		TLR10_HUMAN (1-785): 1e-111: 360: 46.25
+	Mm
		1113883 Q3Y597_MOUSE (19-245): 4.65e-97: 299: 48.25		TLR6_MOUSE (5-780): 5.97e-124: 392: 59.92
+	Hs
		177592 SIGL5_HUMAN (1-551): 1.91e-116: 357: 100.00		TLR2_HUMAN (20-776): 9.9e-92: 306: 26.78
+	Mm
		1113884 Q3Y597_MOUSE (19-245): 4.65e-97: 299: 48.25		TLR2_MOUSE (1-776): 3.13e-95: 316: 27.27
+	Mm
		1265318 SIGL5_MOUSE (1-551): 5.75e-83: 271: 43.77		TLR2_MOUSE (1-776): 3.13e-95: 316: 27.27
+	Mm
		292557 ROBO1_MOUSE (4-547): 3.06e-83: 285: 15.07		SLIT3_MOUSE (9-637): 2.5e-51: 196: 14.03
+	Hs
		177608 SIGL5_HUMAN (1-551): 1.91e-116: 357: 100.00		TLR8_HUMAN (7-636): 2.05e-27: 121: 13.19
+	Hs
		177607 SIGL5_HUMAN (1-551): 1.91e-116: 357: 100.00		TLR9_HUMAN (13-575): 1.37e-25: 115: 13.70
+	Hs
		177610 SIGL5_HUMAN (1-551): 1.91e-116: 357: 100.00		TLR7_HUMAN (25-575): 2.01e-23: 108: 12.71
+	Hs
		177591 SIGL5_HUMAN (1-551): 1.91e-116: 357: 100.00		TLR5_HUMAN (1-397): 9.11e-16: 83.9: 11.48
+	Mm
		885976 Q3Y597_MOUSE (19-245): 4.65e-97: 299: 48.25		TLR8_MOUSE (20-637): 1.38e-29: 128: 13.40
+	Hs
		120112 SIGL5_HUMAN (1-551): 1.91e-116: 357: 100.00		TLR4_HUMAN (1-439): 4.31e-10: 65.4: 11.45
+	Hs
		177589 SIGL5_HUMAN (1-551): 1.91e-116: 357: 100.00		TLR3_HUMAN (250-578): 9.52e-10: 64.2: 12.36
+	Mm
		885974 Q3Y597_MOUSE (19-245): 4.65e-97: 299: 48.25		TLR7_MOUSE (28-575): 7.63e-26: 116: 13.32
+	Mm
		1113882 Q3Y597_MOUSE (19-245): 4.65e-97: 299: 48.25		TLR1_MOUSE (1-140): 5.57e-11: 68.1: 15.60
+	Mm
		1265316 SIGL5_MOUSE (1-551): 5.75e-83: 271: 43.77		TLR5_MOUSE (1-397): 5.44e-15: 81.2: 12.20
+	Mm
		1265315 SIGL5_MOUSE (1-551): 5.75e-83: 271: 43.77		TLR1_MOUSE (1-140): 5.57e-11: 68.1: 15.60
+	Mm
		1265317 SIGL5_MOUSE (1-551): 5.75e-83: 271: 43.77		TLR4_MOUSE (1-460): 2.93e-10: 66.2: 13.28
+	Hs
		120171 SIG11_HUMAN (10-550): 1.07e-50: 186: 34.46		TLR4_HUMAN (1-439): 4.31e-10: 65.4: 11.45