HitPredict

Interactor 1: BIRC5 (O15392)
Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor 4) (Apoptosis inhibitor survivin)
Gene: BIRC5

Interactor 2: DBLOH (Q9NR28)
Diablo IAP-binding mitochondrial protein (Diablo homolog, mitochondrial) (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspase) (Smac) [Cleaved into: Diablo IAP-binding mitochondrial protein, cleaved form]
Gene: DIABLO

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.90 1.00 0.953

The method score is based on:

Property Details
Experiments 21536684, 14699067, 23251006, 12660240, 15541727, 16540654
Identification Methods pull down, fluorescent resonance energy transfer, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains BIR~Smac_DIABLO
Common GO terms GO:0005829 - cytosol
GO:0006915 - apoptotic process
Homologous interactions 11

Homologous interactions

Color coding for hit scores

1 142
Hs

1 239
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Mm
+ Hs
+ Hs
+ Mm
+ Rn

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024