HitPredict

Interactor 1: NMDE4 (O15399)
Glutamate receptor ionotropic, NMDA 2D (GluN2D) (EB11) (Glutamate [NMDA] receptor subunit epsilon-4) (N-methyl D-aspartate receptor subtype 2D) (NMDAR2D) (NR2D)
Gene: GRIN2D

Interactor 2: DLG1 (Q12959)
Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg)
Gene: DLG1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	30126976
Identification Methods	p8 filamentous phage display
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005789 - endoplasmic reticulum membrane GO:0005886 - plasma membrane GO:0098839 - postsynaptic density membrane GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1336 Hs			1 904
+	Hs
		1021492 NMDE3_HUMAN (5-1303): 0: 762: 46.86		DLG1_HUMAN (1-904): 0: 725: 100.00
+	Hs
		1021485 NMDE2_HUMAN (12-996): 0: 758: 48.29		DLG1_HUMAN (1-904): 0: 725: 100.00
+	Rn
		962663 NMDE2_RAT (12-996): 0: 757: 48.19		DLG1_RAT (1-904): 0: 701: 92.54
+	Rn
		962671 NMDE3_RAT (5-1264): 0: 759: 47.92		DLG3_RAT (99-904): 0: 590: 64.57
+	Hs
		1060478 NMDE3_HUMAN (5-1303): 0: 762: 46.86		DLG3_HUMAN (139-904): 0: 585: 66.28
+	Rn
		962664 NMDE2_RAT (12-996): 0: 757: 48.19		DLG3_RAT (99-904): 0: 590: 64.57
+	Hs
		1028145 NMDE2_HUMAN (12-996): 0: 758: 48.29		DLG3_HUMAN (139-904): 0: 585: 66.28
+	Mm
		936175 NMDE2_MOUSE (12-996): 0: 752: 48.09		DLG3_MOUSE (99-904): 0: 589: 64.69
+	Hs
		178305 NMDE4_HUMAN (24-1336): 0: 868: 100.00		DLG4_HUMAN (86-493): 2.62e-24: 111: 15.64
+	Mm
		976160 NMDE4_MOUSE (24-1336): 0: 846: 95.89		DLG4_MOUSE (86-477): 2.03e-24: 111: 16.07
+	Rn
		677785 NMDE4_RAT (24-1336): 0: 842: 95.43		DLG4_RAT (86-493): 2.93e-24: 111: 15.40
+	Mm
		963785 NMDE3_MOUSE (5-1264): 0: 782: 48.34		DLG4_MOUSE (86-477): 2.03e-24: 111: 16.07
+	Hs
		942343 NMDE3_HUMAN (5-1303): 0: 762: 46.86		DLG4_HUMAN (86-493): 2.62e-24: 111: 15.64
+	Rn
		677782 NMDE3_RAT (5-1264): 0: 759: 47.92		DLG4_RAT (86-493): 2.93e-24: 111: 15.40
+	Hs
		942337 NMDE2_HUMAN (12-996): 0: 758: 48.29		DLG4_HUMAN (86-493): 2.62e-24: 111: 15.64
+	Rn
		677781 NMDE2_RAT (12-996): 0: 757: 48.19		DLG4_RAT (86-493): 2.93e-24: 111: 15.40
+	Hs
		1028139 NMDE2_HUMAN (12-996): 0: 758: 48.29		SCRIB_HUMAN (217-396): 1.59e-23: 109: 41.49
+	Hs
		761199 GRIK1_HUMAN (44-879): 0: 755: 19.49		DLG4_HUMAN (86-493): 2.62e-24: 111: 15.64
+	Hs
		1028140 NMDE2_HUMAN (12-996): 0: 758: 48.29		DLG2_HUMAN (393-627): 7.26e-21: 100: 24.48
+	Rn
		962666 NMDE2_RAT (12-996): 0: 757: 48.19		DLG2_RAT (393-627): 2.93e-21: 101: 24.48