HitPredict

Interactor 1: STX7 (O15400)
Syntaxin-7
Gene: STX7

Interactor 2: VAMP4 (O75379)
Vesicle-associated membrane protein 4 (VAMP-4)
Gene: VAMP4

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.950

Property	Details
Experiments	19557002, 28514442, 33961781, 26186194, 34079125, 35271311
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SNARE~Synaptobrevin
Common GO terms	GO:0005764 - lysosome GO:0005768 - endosome GO:0005886 - plasma membrane GO:0031201 - SNARE complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 261 Hs			1 141
+	Mm
		936372 Q8BH40_MOUSE (1-259): 1.02e-74: 229: 94.98		VAMP7_MOUSE (15-139): 2.4e-33: 118: 28.00
+	Hs
		178445 STX7_HUMAN (1-261): 9.25e-70: 217: 100.00		VAMP7_HUMAN (15-139): 2.43e-33: 118: 27.20
+	Mm
		926191 Q8BH40_MOUSE (1-259): 1.02e-74: 229: 94.98		VAMP3_MOUSE (42-118): 1.51e-26: 97.4: 37.66
+	Mm
		926344 Q8BH40_MOUSE (1-259): 1.02e-74: 229: 94.98		VAMP2_MOUSE (46-122): 9.98e-26: 95.5: 35.07
+	Rn
		699183 STX1A_RAT (7-259): 2.77e-65: 206: 24.90		VAMP7_RAT (15-139): 1.14e-33: 118: 27.20
+	Mm
		250840 STX7_MOUSE (1-259): 1.22e-72: 224: 94.21		VAMP2_MOUSE (46-122): 9.98e-26: 95.5: 35.07
+	Mm
		250785 Q8BH40_MOUSE (1-259): 1.02e-74: 229: 94.98		VAMP8_MOUSE (41-116): 9.48e-24: 90.1: 28.95
+	Hs
		178551 STX7_HUMAN (1-261): 9.25e-70: 217: 100.00		VAMP3_HUMAN (47-119): 2.22e-26: 96.7: 41.10
+	Hs
		178472 STX7_HUMAN (1-261): 9.25e-70: 217: 100.00		VAMP2_HUMAN (46-122): 9.98e-26: 95.5: 35.07
+	Hs
		178753 STX7_HUMAN (1-261): 9.25e-70: 217: 100.00		VAMP8_HUMAN (41-120): 1.87e-25: 94.3: 27.50
+	Rn
		699182 STX1A_RAT (7-259): 2.77e-65: 206: 24.90		VAMP1_RAT (32-125): 5.09e-29: 103: 31.92
+	Hs
		699263 STX2_HUMAN (7-256): 2.04e-65: 207: 27.13		VAMP3_HUMAN (47-119): 2.22e-26: 96.7: 41.10
+	Hs
		699254 STX2_HUMAN (7-256): 2.04e-65: 207: 27.13		VAMP2_HUMAN (46-122): 9.98e-26: 95.5: 35.07
+	Mm
		192845 STX1A_MOUSE (7-259): 3.19e-65: 206: 24.90		VAMP2_MOUSE (46-122): 9.98e-26: 95.5: 35.07
+	Rn
		699175 STX1A_RAT (7-259): 2.77e-65: 206: 24.90		VAMP2_RAT (46-122): 9.98e-26: 95.5: 35.07
+	Hs
		699284 STX2_HUMAN (7-256): 2.04e-65: 207: 27.13		VAMP8_HUMAN (41-120): 1.87e-25: 94.3: 27.50
+	Ce
		137701 STX1A_CAEEL (2-259): 8.94e-65: 205: 22.02		SYB1_CAEEL (48-120): 1.14e-25: 95.1: 36.99
+	Rn
		699186 STX1A_RAT (7-259): 2.77e-65: 206: 24.90		VAMP8_RAT (44-116): 5.41e-24: 90.5: 30.14
+	Hs
		178339 STX7_HUMAN (1-261): 9.25e-70: 217: 100.00		VAMP5_HUMAN (52-118): 5.78e-18: 75.8: 31.34
+	Hs
		306763 STX2_HUMAN (7-256): 2.04e-65: 207: 27.13		VAMP5_HUMAN (52-118): 5.78e-18: 75.8: 31.34