HitPredict

Interactor 1: STX7 (O15400)
Syntaxin-7
Gene: STX7

Interactor 2: SNAA (P54920)
Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha)
Gene: NAPA

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.952

Property	Details
Experiments	30833792, 9417091, 26186194, 28514442, 33961781, 35271311
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	SNAP~SNARE
Common GO terms	GO:0000149 - SNARE binding GO:0005886 - plasma membrane GO:0006886 - intracellular protein transport GO:0019905 - syntaxin binding GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 261 Hs			1 295
+	Hs
		178768 STX7_HUMAN (1-261): 9.25e-70: 217: 100.00		SNAB_HUMAN (1-292): 6.03e-113: 329: 84.25
+	Mm
		192858 STX1A_MOUSE (7-259): 3.19e-65: 206: 24.90		SNAA_MOUSE (1-295): 2.18e-113: 330: 98.31
+	Hs
		699286 STX2_HUMAN (7-256): 2.04e-65: 207: 27.13		SNAB_HUMAN (1-292): 6.03e-113: 329: 84.25
+	Rn
		699171 STX1A_RAT (7-259): 2.77e-65: 206: 24.90		SNAA_RAT (1-295): 8.43e-113: 329: 98.31
+	Hs
		873547 STX1A_HUMAN (6-259): 6.04e-65: 205: 24.05		SNAA_HUMAN (1-295): 2.13e-113: 330: 100.00
+	Hs
		1083986 STX1A_HUMAN (6-259): 6.04e-65: 205: 24.05		SNAB_HUMAN (1-292): 6.03e-113: 329: 84.25
+	Hs
		898845 STX1B_HUMAN (7-258): 2.12e-64: 204: 22.31		SNAB_HUMAN (1-292): 6.03e-113: 329: 84.25
+	Hs
		873559 STX12_HUMAN (10-244): 3.42e-58: 188: 54.01		SNAA_HUMAN (1-295): 2.13e-113: 330: 100.00
+	Hs
		1205369 STX12_HUMAN (10-244): 3.42e-58: 188: 54.01		SNAB_HUMAN (1-292): 6.03e-113: 329: 84.25
+	Dm
		1095554 STX1A_DROME (1-256): 1.06e-63: 202: 22.73		SNAP_DROME (5-295): 7.84e-105: 308: 61.51
+	Hs
		873540 STX3_HUMAN (4-237): 2.81e-52: 173: 23.33		SNAA_HUMAN (1-295): 2.13e-113: 330: 100.00
+	Hs
		1030185 STX3_HUMAN (4-237): 2.81e-52: 173: 23.33		SNAB_HUMAN (1-292): 6.03e-113: 329: 84.25
+	Hs
		1328433 X5D7S1_HUMAN (6-258): 7.74e-53: 173: 22.05		SNAB_HUMAN (1-292): 6.03e-113: 329: 84.25
+	Hs
		873535 STX4_HUMAN (5-256): 7.24e-50: 167: 23.85		SNAA_HUMAN (1-295): 2.13e-113: 330: 100.00
+	At
		955696 SYP22_ARATH (3-245): 3.86e-59: 190: 29.63		SNAA2_ARATH (12-291): 2.59e-91: 274: 41.64
+	At
		1107367 SYP21_ARATH (4-245): 2.26e-55: 180: 32.25		SNAA2_ARATH (12-291): 2.59e-91: 274: 41.64
+	Hs
		178743 STX7_HUMAN (1-261): 9.25e-70: 217: 100.00		SNAG_HUMAN (4-265): 6.75e-68: 215: 23.40
+	Hs
		1205360 STX12_HUMAN (10-244): 3.42e-58: 188: 54.01		SNAG_HUMAN (4-265): 6.75e-68: 215: 23.40
+	Dm
		1098094 STX1A_DROME (1-256): 1.06e-63: 202: 22.73		Q9U6R9_DROME (4-265): 3.84e-58: 190: 18.49
+	Dm
		1098102 STX1A_DROME (1-256): 1.06e-63: 202: 22.73		Q9VH25_DROME (18-265): 1.8e-53: 177: 17.53