HitPredict

Interactor 1: RPA34 (O15446)
DNA-directed RNA polymerase I subunit RPA34 (A34.5) (Antisense to ERCC-1 protein) (ASE-1) (CD3-epsilon-associated protein) (CD3E-associated protein) (DNA-directed RNA polymerase I subunit G) (RNA polymerase I-associated factor PAF49)
Gene: POLR1G

Interactor 2: RPA2 (Q9H9Y6)
DNA-directed RNA polymerase I subunit RPA2 (RNA polymerase I subunit 2) (EC 2.7.7.6) (DNA-directed RNA polymerase I 135 kDa polypeptide) (RPA135)
Gene: POLR1B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	24981860, 34079125, 35271311
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RNA_polI_A34~RNA_pol_Rpa2_4, RNA_polI_A34~RNA_pol_Rpb2_1, RNA_polI_A34~RNA_pol_Rpb2_6
Common GO terms	GO:0001650 - fibrillar center GO:0005654 - nucleoplasm GO:0005694 - chromosome GO:0005736 - RNA polymerase I complex GO:0005829 - cytosol and 1 others more... GO:0009303 - rRNA transcription
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 510 Hs			1 1135
+	Hs
		179560 RPA34_HUMAN (1-510): 8.02e-73: 241: 100.00		RPB2_HUMAN (18-1135): 0: 1296: 27.87
+	Hs
		179852 RPA34_HUMAN (1-510): 8.02e-73: 241: 100.00		RPC2_HUMAN (12-1134): 0: 1210: 28.58
+	Hs
		676883 MDC1_HUMAN (88-510): 8.73e-09: 60.4: 10.54		RPB2_HUMAN (18-1135): 0: 1296: 27.87