Interactor 1: TLR3 (O15455)
Toll-like receptor 3 (CD antigen CD283)
Gene: TLR3

Interactor 2: TLR3 (O15455)
Toll-like receptor 3 (CD antigen CD283)
Gene: TLR3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.71 1.00 0.843

The method score is based on:

Property Details
Experiments 18172197, 23155421, 25217833
Identification Methods molecular sieving, cosedimentation in solution, tox-r dimerization assay, nuclear magnetic resonance
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains LRR_6~LRR_6, LRR_6~LRR_8, LRR_8~LRR_8, TIR~TIR, Tlr3_TMD~Tlr3_TMD
Common GO terms GO:0000139 - Golgi membrane
GO:0001774 - microglial cell activation
GO:0002224 - toll-like receptor signaling pathway
GO:0002730 - regulation of dendritic cell cytokine production
GO:0003725 - double-stranded RNA binding
and 56 others

more...

Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 904
Hs

1 904
+ Mm
+ Zm
+ Hs
+ Bt
+ Mm
+ Mm
+ At
+ Hs
+ At
+ At
+ Hs
+ At
+ At
+ Hs
+ At
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+ At
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024