Interactor 1: TLR3 (O15455)
Toll-like receptor 3 (CD antigen CD283)
Gene: TLR3

Interactor 2: M3K7 (O43318)
Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
Gene: MAP3K7

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.62 1.00 0.789

The method score is based on:

Property Details
Experiments 12609980, 16115877
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains LRR_8~PK_Tyr_Ser-Thr
Common GO terms GO:0005737 - cytoplasm
GO:0005789 - endoplasmic reticulum membrane
GO:0005886 - plasma membrane
GO:0007250 - activation of NF-kappaB-inducing kinase activity
GO:0007252 - I-kappaB phosphorylation
and 6 others

more...

Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 904
Hs

1 606
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024