HitPredict

Interactor 1: TLR3 (O15455)
Toll-like receptor 3 (CD antigen CD283)
Gene: TLR3

Interactor 2: SIGL6 (O43699)
Sialic acid-binding Ig-like lectin 6 (Siglec-6) (CD33 antigen-like 1) (CDw327) (Obesity-binding protein 1) (OB-BP1) (CD antigen CD327)
Gene: SIGLEC6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	25187624
Identification Methods	enzyme linked immunosorbent assay
Interaction Type	physical association

Property	Details
Interacting Pfam domains	I-set~LRR_8, LRR_8~ig, LRR_8~V-set
Common GO terms	GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 904 Hs			1 453
+	Hs
		179970 TLR3_HUMAN (1-904): 2.14e-155: 481: 100.00		SIGL9_HUMAN (33-453): 3.87e-76: 247: 49.89
+	Hs
		179969 TLR3_HUMAN (1-904): 2.14e-155: 481: 100.00		SIGL7_HUMAN (23-453): 3.93e-74: 241: 50.11
+	Hs
		211423 TLR9_HUMAN (1-902): 1.39e-102: 344: 21.01		SIGL6_HUMAN (1-453): 1.09e-99: 307: 100.00
+	Hs
		177589 TLR3_HUMAN (1-904): 2.14e-155: 481: 100.00		SIGL5_HUMAN (44-453): 2.75e-27: 116: 17.12
+	Hs
		179956 TLR3_HUMAN (1-904): 2.14e-155: 481: 100.00		SIG11_HUMAN (39-452): 9.81e-27: 115: 19.56
+	Hs
		1344383 TLR9_HUMAN (1-902): 1.39e-102: 344: 21.01		SIGL9_HUMAN (33-453): 3.87e-76: 247: 49.89
+	Hs
		179954 TLR3_HUMAN (1-904): 2.14e-155: 481: 100.00		SIG10_HUMAN (77-452): 3.58e-23: 104: 17.00
+	Mm
		885977 TLR8_MOUSE (23-901): 7.9e-99: 334: 21.28		Q6PJ50_MOUSE (31-453): 9.65e-74: 241: 44.19
+	Mm
		1265201 TLR4_MOUSE (46-897): 7.68e-95: 319: 19.70		SIG12_MOUSE (28-453): 2.65e-74: 242: 44.12
+	Mm
		1162020 TLR4_MOUSE (46-897): 7.68e-95: 319: 19.70		Q6PJ50_MOUSE (31-453): 9.65e-74: 241: 44.19
+	Mm
		1144428 TLR3_MOUSE (8-904): 2.26e-144: 452: 79.93		CD33_MOUSE (155-419): 1.29e-23: 104: 17.42
+	Mm
		885976 TLR8_MOUSE (23-901): 7.9e-99: 334: 21.28		Q3Y597_MOUSE (18-252): 9.41e-65: 212: 52.89
+	Mm
		1113884 TLR2_MOUSE (134-899): 4.2e-95: 318: 20.34		Q3Y597_MOUSE (18-252): 9.41e-65: 212: 52.89
+	Hs
		177607 TLR9_HUMAN (1-902): 1.39e-102: 344: 21.01		SIGL5_HUMAN (44-453): 2.75e-27: 116: 17.12
+	Mm
		1265316 TLR5_MOUSE (5-900): 2.42e-95: 320: 19.81		SIGL5_MOUSE (24-453): 9.77e-31: 126: 18.20
+	Mm
		1265317 TLR4_MOUSE (46-897): 7.68e-95: 319: 19.70		SIGL5_MOUSE (24-453): 9.77e-31: 126: 18.20
+	Mm
		1144431 TLR5_MOUSE (5-900): 2.42e-95: 320: 19.81		CD33_MOUSE (155-419): 1.29e-23: 104: 17.42
+	Mm
		1144432 TLR2_MOUSE (134-899): 4.2e-95: 318: 20.34		CD33_MOUSE (155-419): 1.29e-23: 104: 17.42
+	Mm
		722909 TLR5_MOUSE (5-900): 2.42e-95: 320: 19.81		CD22_MOUSE (7-255): 2.17e-15: 80.7: 16.73
+	Mm
		722910 TLR2_MOUSE (134-899): 4.2e-95: 318: 20.34		CD22_MOUSE (7-255): 2.17e-15: 80.7: 16.73