HitPredict

Interactor 1: TLR3 (O15455)
Toll-like receptor 3 (CD antigen CD283)
Gene: TLR3

Interactor 2: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.60 1.00 0.776

The method score is based on:

Property Details
Experiments 15502848, 16858407
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains LRR_8~SH2
Common GO terms GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0016020 - membrane
GO:0032760 - positive regulation of tumor necrosis factor production
GO:0045671 - negative regulation of osteoclast differentiation
and 1 others

more...
Homologous interactions 3

Homologous interactions

Color coding for hit scores

1 904
Hs

1 724
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024