HitPredict

Interactor 1: TLR3 (O15455)
Toll-like receptor 3 (CD antigen CD283)
Gene: TLR3

Interactor 2: SIGL7 (Q9Y286)
Sialic acid-binding Ig-like lectin 7 (Siglec-7) (Adhesion inhibitory receptor molecule 1) (AIRM-1) (CDw328) (D-siglec) (QA79 membrane protein) (p75) (CD antigen CD328)
Gene: SIGLEC7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	25187624
Identification Methods	enzyme linked immunosorbent assay
Interaction Type	physical association

Property	Details
Interacting Pfam domains	LRR_8~V-set
Common GO terms	GO:0005886 - plasma membrane GO:0038023 - signaling receptor activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 904 Hs			1 467
+	Hs
		179970 TLR3_HUMAN (1-904): 2.14e-155: 481: 100.00		SIGL9_HUMAN (11-467): 5.54e-92: 288: 73.71
+	Hs
		179919 TLR3_HUMAN (1-904): 2.14e-155: 481: 100.00		SIGL6_HUMAN (16-467): 1.26e-89: 282: 48.79
+	Hs
		1344383 TLR9_HUMAN (1-902): 1.39e-102: 344: 21.01		SIGL9_HUMAN (11-467): 5.54e-92: 288: 73.71
+	Hs
		211423 TLR9_HUMAN (1-902): 1.39e-102: 344: 21.01		SIGL6_HUMAN (16-467): 1.26e-89: 282: 48.79
+	Hs
		177589 TLR3_HUMAN (1-904): 2.14e-155: 481: 100.00		SIGL5_HUMAN (39-467): 8.62e-35: 138: 18.74
+	Hs
		179956 TLR3_HUMAN (1-904): 2.14e-155: 481: 100.00		SIG11_HUMAN (77-466): 5.96e-32: 131: 23.46
+	Mm
		885977 TLR8_MOUSE (23-901): 7.9e-99: 334: 21.28		Q6PJ50_MOUSE (11-467): 1.27e-81: 261: 51.19
+	Hs
		179954 TLR3_HUMAN (1-904): 2.14e-155: 481: 100.00		SIG10_HUMAN (77-465): 1.82e-25: 111: 15.13
+	Mm
		1265201 TLR4_MOUSE (46-897): 7.68e-95: 319: 19.70		SIG12_MOUSE (11-467): 3.02e-82: 263: 51.40
+	Mm
		1162020 TLR4_MOUSE (46-897): 7.68e-95: 319: 19.70		Q6PJ50_MOUSE (11-467): 1.27e-81: 261: 51.19
+	Mm
		885976 TLR8_MOUSE (23-901): 7.9e-99: 334: 21.28		Q3Y597_MOUSE (32-254): 3.08e-69: 224: 54.02
+	Mm
		1113884 TLR2_MOUSE (134-899): 4.2e-95: 318: 20.34		Q3Y597_MOUSE (32-254): 3.08e-69: 224: 54.02
+	Mm
		1144428 TLR3_MOUSE (8-904): 2.26e-144: 452: 79.93		CD33_MOUSE (156-422): 9.68e-17: 83.8: 20.83
+	Hs
		177607 TLR9_HUMAN (1-902): 1.39e-102: 344: 21.01		SIGL5_HUMAN (39-467): 8.62e-35: 138: 18.74
+	Mm
		1265316 TLR5_MOUSE (5-900): 2.42e-95: 320: 19.81		SIGL5_MOUSE (68-467): 1.58e-30: 126: 19.02
+	Mm
		1265317 TLR4_MOUSE (46-897): 7.68e-95: 319: 19.70		SIGL5_MOUSE (68-467): 1.58e-30: 126: 19.02
+	Mm
		722909 TLR5_MOUSE (5-900): 2.42e-95: 320: 19.81		CD22_MOUSE (20-365): 6.37e-22: 101: 17.61
+	Mm
		722910 TLR2_MOUSE (134-899): 4.2e-95: 318: 20.34		CD22_MOUSE (20-365): 6.37e-22: 101: 17.61
+	Mm
		1144431 TLR5_MOUSE (5-900): 2.42e-95: 320: 19.81		CD33_MOUSE (156-422): 9.68e-17: 83.8: 20.83
+	Mm
		1144432 TLR2_MOUSE (134-899): 4.2e-95: 318: 20.34		CD33_MOUSE (156-422): 9.68e-17: 83.8: 20.83