HitPredict

Interactor 1: RPB4 (O15514)
DNA-directed RNA polymerase II subunit RPB4 (RNA polymerase II subunit B4) (DNA-directed RNA polymerase II subunit D) (RNA polymerase II 16 kDa subunit) (RPB16)
Gene: POLR2D

Interactor 2: MED14 (O60244)
Mediator of RNA polymerase II transcription subunit 14 (Activator-recruited cofactor 150 kDa component) (ARC150) (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (RGR1 homolog) (hRGR1) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150)
Gene: MED14

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	24981860, 35271311
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 142 Hs			1 1454
+	Sc
		581331 RPB4_YEAST (42-140): 3.4e-27: 102: 35.58		MED14_YEAST (2-463): 8.6e-138: 453: 18.45
+	Hs
		123787 RPB4_HUMAN (1-142): 4e-59: 181: 100.00		SPT5H_HUMAN (1062-1272): 9.25e-11: 68.8: 14.41
+	Bt
		102290 RPB4_BOVIN (1-142): 5.43e-59: 181: 99.30		RPB1_BOVIN (1059-1159): 8.45e-09: 62.5: 23.30
+	Hs
		181390 RPB4_HUMAN (1-142): 4e-59: 181: 100.00		RPB1_HUMAN (1059-1159): 8.88e-09: 62.5: 23.30