HitPredict

Interactor 1: CFLAR (O15519)
CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Inhibitor of FLICE) (I-FLICE) (MACH-related inducer of toxicity) (MRIT) (Usurpin) [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12]
Gene: CFLAR

Interactor 2: TNF10 (P50591)
Tumor necrosis factor ligand superfamily member 10 (Apo-2 ligand) (Apo-2L) (TNF-related apoptosis-inducing ligand) (Protein TRAIL) (CD antigen CD253)
Gene: TNFSF10

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	0.60	0.714

Property	Details
Experiments	19432816, 22266862, 21822306, 20097879, 21525171, 23678861
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006915 - apoptotic process GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 480 Hs			1 281
+	Hs
		841073 CASP8_HUMAN (6-478): 8.27e-152: 442: 24.85		TNF10_HUMAN (1-281): 5.49e-130: 371: 100.00
+	Hs
		841079 CASPA_HUMAN (4-453): 5.22e-122: 368: 25.41		TNF10_HUMAN (1-281): 5.49e-130: 371: 100.00
+	Hs
		181593 CFLAR_HUMAN (1-480): 5.94e-178: 509: 100.00		TNFL6_HUMAN (82-280): 3.97e-55: 181: 25.50
+	Mm
		193421 CFLAR_MOUSE (1-480): 2.03e-170: 490: 65.21		TNFL6_MOUSE (82-280): 6.36e-57: 185: 24.50
+	Rn
		83168 C0H5Y5_RAT (1-480): 2.23e-172: 495: 66.46		TNFA_RAT (121-280): 3.84e-51: 169: 19.64
+	Hs
		788162 CASP3_HUMAN (209-479): 8.43e-89: 274: 22.53		TNF10_HUMAN (1-281): 5.49e-130: 371: 100.00
+	Hs
		815680 CASP8_HUMAN (6-478): 8.27e-152: 442: 24.85		TNFL6_HUMAN (82-280): 3.97e-55: 181: 25.50
+	Hs
		352616 CASP8_HUMAN (6-478): 8.27e-152: 442: 24.85		TNFA_HUMAN (94-280): 1.57e-50: 167: 19.07
+	Hs
		815704 CASPA_HUMAN (4-453): 5.22e-122: 368: 25.41		TNFL6_HUMAN (82-280): 3.97e-55: 181: 25.50
+	Rn
		561445 CASPC_RAT (112-479): 2.97e-101: 311: 15.68		TNFA_RAT (121-280): 3.84e-51: 169: 19.64
+	Rn
		61823 A6JI19_RAT (181-477): 1.45e-92: 285: 20.06		TNFA_RAT (121-280): 3.84e-51: 169: 19.64
+	Rn
		561409 CASP3_RAT (224-479): 1.28e-87: 271: 22.30		TNFA_RAT (121-280): 3.84e-51: 169: 19.64
+	Rn
		561447 Q99M88_RAT (98-397): 6.02e-74: 239: 20.96		TNFA_RAT (121-280): 3.84e-51: 169: 19.64