HitPredict

Interactor 1: CFLAR (O15519)
CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Inhibitor of FLICE) (I-FLICE) (MACH-related inducer of toxicity) (MRIT) (Usurpin) [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12]
Gene: CFLAR

Interactor 2: TRAF1 (Q13077)
TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6)
Gene: TRAF1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.718

Property	Details
Experiments	25416956, 9208847, 10837247, 32296183, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006915 - apoptotic process GO:0051092 - positive regulation of NF-kappaB transcription factor activity
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 480 Hs			1 416
+	Hs
		1023660 CASP8_HUMAN (6-478): 8.27e-152: 442: 24.85		TRAF1_HUMAN (1-416): 4.57e-172: 489: 100.00
+	Hs
		181605 CFLAR_HUMAN (1-480): 5.94e-178: 509: 100.00		TRAF2_HUMAN (3-415): 4e-124: 370: 38.01
+	Hs
		1023744 CASPA_HUMAN (4-453): 5.22e-122: 368: 25.41		TRAF1_HUMAN (1-416): 4.57e-172: 489: 100.00
+	Hs
		1020664 CASP8_HUMAN (6-478): 8.27e-152: 442: 24.85		TRAF2_HUMAN (3-415): 4e-124: 370: 38.01
+	Hs
		788250 CASP2_HUMAN (79-479): 7.53e-101: 311: 18.71		TRAF1_HUMAN (1-416): 4.57e-172: 489: 100.00
+	Mm
		669121 CASP2_MOUSE (79-479): 2.37e-102: 315: 18.48		TRAF1_MOUSE (1-416): 4.49e-160: 458: 84.38
+	Hs
		1059404 CASP8_HUMAN (6-478): 8.27e-152: 442: 24.85		TRAF6_HUMAN (15-414): 1.57e-103: 318: 22.98
+	Hs
		877026 CASP6_HUMAN (228-479): 7.99e-83: 259: 22.42		TRAF1_HUMAN (1-416): 4.57e-172: 489: 100.00
+	Mm
		292696 CASP8_MOUSE (6-479): 1.68e-146: 429: 24.60		TRAF6_MOUSE (15-414): 1.94e-101: 313: 22.51
+	Mm
		669122 CASP2_MOUSE (79-479): 2.37e-102: 315: 18.48		TRAF2_MOUSE (3-415): 3.91e-127: 378: 37.77
+	Hs
		788249 CASP2_HUMAN (79-479): 7.53e-101: 311: 18.71		TRAF2_HUMAN (3-415): 4e-124: 370: 38.01
+	Hs
		667455 CASP1_HUMAN (109-479): 3.58e-97: 300: 17.24		TRAF2_HUMAN (3-415): 4e-124: 370: 38.01
+	Hs
		1020747 CASPC_HUMAN (122-479): 2.2e-92: 285: 16.85		TRAF2_HUMAN (3-415): 4e-124: 370: 38.01
+	Hs
		876940 CASP7_HUMAN (183-478): 3.6e-92: 283: 21.38		TRAF2_HUMAN (3-415): 4e-124: 370: 38.01
+	Hs
		830308 CASP4_HUMAN (142-479): 9.69e-95: 293: 17.22		TRAF6_HUMAN (15-414): 1.57e-103: 318: 22.98
+	Hs
		181607 CFLAR_HUMAN (1-480): 5.94e-178: 509: 100.00		TRAF3_HUMAN (3-262): 9.64e-11: 65.3: 15.77
+	Hs
		788251 CASP2_HUMAN (79-479): 7.53e-101: 311: 18.71		TRAF3_HUMAN (3-262): 9.64e-11: 65.3: 15.77
+	Hs
		788188 CASP3_HUMAN (209-479): 8.43e-89: 274: 22.53		TRAF3_HUMAN (3-262): 9.64e-11: 65.3: 15.77