Interactor 1: CFLAR (O15519)
CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Inhibitor of FLICE) (I-FLICE) (MACH-related inducer of toxicity) (MRIT) (Usurpin) [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12]
Gene: CFLAR
Interactor 2: CASP8 (Q14790)
Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]
Gene: CASP8
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.98 | 1.00 | 0.993 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 19343040, 21737330, 12887920, 31046799, 9228018, 11741985, 33469115, 35044632, 19710364, 21737329, 15280356, 22864571, 17047155, 26186194, 28514442, 9208847, 9289491, 12215447, 9326610, 33961781 and 8 others
more... |
| Identification Methods | enzymatic study, affinity chromatography technology, two hybrid, pull down, molecular sieving, protease assay, x-ray crystallography, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation |
| Interaction Type | direct interaction, physical association, cleavage reaction, association, protein cleavage |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | DED~DED, Peptidase_C14~Peptidase_C14 |
| Common GO terms | GO:0005123 - death receptor binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006508 - proteolysis GO:0006915 - apoptotic process and 8 others more... |
| Homologous interactions | 18 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
