HitPredict

Interactor 1: SOCS1 (O15524)
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3)
Gene: SOCS1

Interactor 2: KIT (P10721)
Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
Gene: KIT

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.800

Property	Details
Experiments	10022833, 29991678
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0019221 - cytokine-mediated signaling pathway GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 211 Hs			1 976
+	Hs
		256847 SOCS5_HUMAN (3-210): 3.81e-46: 161: 19.44		KIT_HUMAN (1-976): 0: 807: 100.00
+	Hs
		499278 SOCS4_HUMAN (3-210): 8.16e-43: 151: 18.98		KIT_HUMAN (1-976): 0: 807: 100.00
+	Hs
		499291 VAV3_HUMAN (5-209): 1.13e-39: 146: 15.24		KIT_HUMAN (1-976): 0: 807: 100.00
+	Hs
		146585 SOCS2_HUMAN (37-211): 5.65e-43: 144: 28.57		KIT_HUMAN (1-976): 0: 807: 100.00
+	Hs
		147481 SOCS6_HUMAN (66-209): 1.11e-39: 144: 26.06		KIT_HUMAN (1-976): 0: 807: 100.00
+	Hs
		411567 LCK_HUMAN (4-194): 3.94e-39: 142: 13.46		KIT_HUMAN (1-976): 0: 807: 100.00
+	Mm
		193336 SOCS1_MOUSE (1-211): 7.14e-52: 167: 93.87		KIT_MOUSE (1-975): 0: 773: 79.63
+	Mm
		403545 SOCS6_MOUSE (66-209): 7.1e-39: 141: 26.06		KIT_MOUSE (1-975): 0: 773: 79.63
+	Hs
		452495 VAV3_HUMAN (5-209): 1.13e-39: 146: 15.24		PGFRB_HUMAN (30-954): 0: 591: 30.62
+	Hs
		452375 VAV2_HUMAN (1-175): 2.65e-39: 144: 17.68		PGFRB_HUMAN (30-954): 0: 591: 30.62
+	Hs
		181810 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		FLT3_HUMAN (11-968): 1.65e-171: 528: 29.98
+	Hs
		146603 SOCS2_HUMAN (37-211): 5.65e-43: 144: 28.57		FLT3_HUMAN (11-968): 1.65e-171: 528: 29.98
+	Hs
		147491 SOCS6_HUMAN (66-209): 1.11e-39: 144: 26.06		FLT3_HUMAN (11-968): 1.65e-171: 528: 29.98
+	Hs
		411619 LCK_HUMAN (4-194): 3.94e-39: 142: 13.46		FLT3_HUMAN (11-968): 1.65e-171: 528: 29.98
+	Mm
		193364 SOCS2_MOUSE (37-211): 1.07e-42: 144: 28.57		FLT3_MOUSE (11-968): 9.07e-170: 523: 30.16
+	Hs
		181796 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		FGFR3_HUMAN (3-331): 4.6e-51: 195: 13.39
+	Hs
		147484 SOCS6_HUMAN (66-209): 1.11e-39: 144: 26.06		FGFR3_HUMAN (3-331): 4.6e-51: 195: 13.39
+	Dm
		112209 ABL_DROME (14-193): 2.41e-38: 142: 14.06		M9MRE1_DROME (31-495): 6.65e-36: 149: 17.32
+	Mm
		193337 SOCS1_MOUSE (1-211): 7.14e-52: 167: 93.87		CSF1R_MOUSE (6-304): 6.2e-18: 91.3: 13.53
+	Hs
		181766 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		CSF1R_HUMAN (209-511): 1.03e-12: 74.4: 14.10