HitPredict

Interactor 1: SOCS1 (O15524)
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3)
Gene: SOCS1

Interactor 2: SPTB2 (Q01082)
Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1)
Gene: SPTBN1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	33754058
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 211 Hs			1 2364
+	Hs
		411676 LCK_HUMAN (4-194): 3.94e-39: 142: 13.46		SPTB2_HUMAN (1-2364): 0: 751: 100.00
+	Hs
		924482 GRB2_HUMAN (52-181): 4.7e-36: 127: 16.79		SPTB2_HUMAN (1-2364): 0: 751: 100.00
+	Hs
		129277 P85B_HUMAN (75-174): 7.87e-18: 82.9: 25.00		SPTB2_HUMAN (1-2364): 0: 751: 100.00
+	Hs
		211557 GRB2_HUMAN (52-181): 4.7e-36: 127: 16.79		ACTN4_HUMAN (53-525): 6.51e-121: 409: 47.58
+	Hs
		521521 GRB2_HUMAN (52-181): 4.7e-36: 127: 16.79		ACTN1_HUMAN (28-775): 4.31e-92: 323: 34.25
+	Hs
		147511 SOCS6_HUMAN (66-209): 1.11e-39: 144: 26.06		DYST_HUMAN (537-1421): 8.42e-22: 106: 12.00
+	Hs
		411682 LCK_HUMAN (4-194): 3.94e-39: 142: 13.46		DYST_HUMAN (537-1421): 8.42e-22: 106: 12.00
+	Hs
		411715 LCK_HUMAN (4-194): 3.94e-39: 142: 13.46		SPTN1_HUMAN (152-1087): 9.93e-19: 96.3: 16.89
+	Hs
		411637 LCK_HUMAN (4-194): 3.94e-39: 142: 13.46		UTRN_HUMAN (212-2073): 1e-17: 93.2: 10.02
+	Hs
		147521 SOCS6_HUMAN (66-209): 1.11e-39: 144: 26.06		PLEC_HUMAN (222-1144): 1.08e-16: 89.7: 11.59
+	Hs
		924491 GRB2_HUMAN (52-181): 4.7e-36: 127: 16.79		DYST_HUMAN (537-1421): 8.42e-22: 106: 12.00
+	Hs
		411889 LCK_HUMAN (4-194): 3.94e-39: 142: 13.46		MACF1_HUMAN (687-1920): 4.98e-16: 87.6: 12.23
+	Hs
		924555 GRB2_HUMAN (52-181): 4.7e-36: 127: 16.79		SPTN1_HUMAN (152-1087): 9.93e-19: 96.3: 16.89
+	Hs
		924586 GRB2_HUMAN (52-181): 4.7e-36: 127: 16.79		PLEC_HUMAN (222-1144): 1.08e-16: 89.7: 11.59
+	Hs
		164551 LCK_HUMAN (4-194): 3.94e-39: 142: 13.46		SPTN2_HUMAN (1661-2338): 1.76e-11: 72.4: 15.10