HitPredict

Interactor 1: SOCS1 (O15524)
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3)
Gene: SOCS1

Interactor 2: ATR (Q13535)
Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1)
Gene: ATR

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	29991678, 20005840
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PI3_PI4_kinase~SH2
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 211 Hs			1 2644
+	Hs
		146605 SOCS2_HUMAN (37-211): 5.65e-43: 144: 28.57		MTOR_HUMAN (756-2643): 0: 1254: 15.93
+	Dm
		1213724 Q8INY1_DROME (26-210): 6.61e-43: 154: 23.00		TOR_DROME (755-2643): 0: 1224: 16.23
+	Hs
		181854 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		ATM_HUMAN (772-2644): 0: 1145: 18.85
+	Hs
		855830 VAV2_HUMAN (1-175): 2.65e-39: 144: 17.68		TRRAP_HUMAN (1161-2644): 0: 857: 13.71
+	Hs
		557839 NCK1_HUMAN (17-175): 2.39e-36: 132: 21.25		TRRAP_HUMAN (1161-2644): 0: 857: 13.71
+	Hs
		181842 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		PRKDC_HUMAN (1676-2644): 1.8e-143: 506: 16.76
+	Hs
		924472 GRB2_HUMAN (52-181): 4.7e-36: 127: 16.79		PRKDC_HUMAN (1676-2644): 1.8e-143: 506: 16.76
+	Hs
		126189 NCK1_HUMAN (17-175): 2.39e-36: 132: 21.25		PK3CD_HUMAN (2015-2618): 3.97e-106: 369: 15.42
+	Hs
		787365 GRB2_HUMAN (52-181): 4.7e-36: 127: 16.79		PK3CB_HUMAN (2027-2612): 2.66e-101: 355: 13.59
+	Hs
		126198 P55G_HUMAN (79-179): 8.37e-24: 99.8: 21.91		PK3CD_HUMAN (2015-2618): 3.97e-106: 369: 15.42
+	Mm
		193568 P85A_MOUSE (57-180): 1.73e-17: 82.1: 20.64		PK3CD_MOUSE (2015-2618): 6.66e-109: 377: 15.74
+	Mm
		1145021 P55G_MOUSE (79-179): 1.29e-23: 99: 21.91		PK3CB_MOUSE (1993-2612): 1.29e-102: 359: 13.23
+	Hs
		787386 P55G_HUMAN (79-179): 8.37e-24: 99.8: 21.91		PK3CB_HUMAN (2027-2612): 2.66e-101: 355: 13.59
+	Hs
		126184 P85B_HUMAN (75-174): 7.87e-18: 82.9: 25.00		PK3CD_HUMAN (2015-2618): 3.97e-106: 369: 15.42
+	Hs
		126190 P85A_HUMAN (57-180): 1.73e-17: 82.1: 20.64		PK3CD_HUMAN (2015-2618): 3.97e-106: 369: 15.42
+	Hs
		101790 P85A_HUMAN (57-180): 1.73e-17: 82.1: 20.64		F8W9P4_HUMAN (2046-2618): 8.67e-105: 366: 15.05
+	Mm
		643106 P85A_MOUSE (57-180): 1.73e-17: 82.1: 20.64		PK3CB_MOUSE (1993-2612): 1.29e-102: 359: 13.23
+	Dm
		186278 O18683_DROME (79-202): 3.04e-24: 101: 19.55		P91634_DROME (2001-2619): 2.46e-95: 337: 12.64
+	Hs
		129231 P85B_HUMAN (75-174): 7.87e-18: 82.9: 25.00		PK3CB_HUMAN (2027-2612): 2.66e-101: 355: 13.59
+	Hs
		655252 P85A_HUMAN (57-180): 1.73e-17: 82.1: 20.64		PK3CB_HUMAN (2027-2612): 2.66e-101: 355: 13.59