HitPredict

Interactor 1: SOCS1 (O15524)
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3)
Gene: SOCS1

Interactor 2: CUL2 (Q13617)
Cullin-2 (CUL-2)
Gene: CUL2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	29991678, 19327355
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cullin~SOCS_box
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 211 Hs			1 745
+	Hs
		1041477 CISH_HUMAN (22-211): 6.28e-41: 141: 26.45		CUL2_HUMAN (1-745): 0: 840: 100.00
+	Hs
		146625 SOCS2_HUMAN (37-211): 5.65e-43: 144: 28.57		CUL4A_HUMAN (4-745): 0: 773: 26.86
+	Hs
		855795 VAV2_HUMAN (1-175): 2.65e-39: 144: 17.68		CUL4A_HUMAN (4-745): 0: 773: 26.86
+	Hs
		1042817 VAV3_HUMAN (5-209): 1.13e-39: 146: 15.24		CUL3_HUMAN (1-745): 0: 768: 26.38
+	Hs
		411713 LCK_HUMAN (4-194): 3.94e-39: 142: 13.46		CUL3_HUMAN (1-745): 0: 768: 26.38
+	Hs
		147421 SOCS3_HUMAN (39-207): 3.53e-40: 138: 27.73		CUL4B_HUMAN (4-745): 0: 771: 27.79
+	Hs
		146692 SOCS7_HUMAN (22-209): 5.3e-49: 169: 22.75		CUL5_HUMAN (7-745): 0: 627: 26.69
+	Mm
		193357 SOCS1_MOUSE (1-211): 7.14e-52: 167: 93.87		CUL5_MOUSE (7-745): 0: 628: 26.82
+	Hs
		181885 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		CUL5_HUMAN (7-745): 0: 627: 26.69
+	Mm
		1265273 SOCS4_MOUSE (3-210): 2.25e-46: 160: 18.98		CUL5_MOUSE (7-745): 0: 628: 26.82
+	Hs
		256856 SOCS5_HUMAN (3-210): 3.81e-46: 161: 19.44		CUL5_HUMAN (7-745): 0: 627: 26.69
+	Mm
		222648 SOCS5_MOUSE (3-210): 4.32e-45: 158: 18.98		CUL5_MOUSE (7-745): 0: 628: 26.82
+	Hs
		1263831 SOCS4_HUMAN (3-210): 8.16e-43: 151: 18.98		CUL5_HUMAN (7-745): 0: 627: 26.69
+	Mm
		193366 SOCS2_MOUSE (37-211): 1.07e-42: 144: 28.57		CUL5_MOUSE (7-745): 0: 628: 26.82
+	Hs
		146642 SOCS2_HUMAN (37-211): 5.65e-43: 144: 28.57		CUL5_HUMAN (7-745): 0: 627: 26.69
+	Hs
		147544 SOCS6_HUMAN (66-209): 1.11e-39: 144: 26.06		CUL5_HUMAN (7-745): 0: 627: 26.69
+	Mm
		1143676 CISH_MOUSE (22-211): 1.94e-41: 142: 26.56		CUL5_MOUSE (7-745): 0: 628: 26.82
+	Mm
		1322060 SOCS6_MOUSE (66-209): 7.1e-39: 141: 26.06		CUL5_MOUSE (7-745): 0: 628: 26.82
+	Mm
		193394 SOCS3_MOUSE (39-207): 3.5e-41: 141: 27.60		CUL5_MOUSE (7-745): 0: 628: 26.82
+	Hs
		1274062 CISH_HUMAN (22-211): 6.28e-41: 141: 26.45		CUL5_HUMAN (7-745): 0: 627: 26.69