HitPredict

Interactor 1: PDPK1 (O15530)
3-phosphoinositide-dependent protein kinase 1 (hPDK1) (EC 2.7.11.1)
Gene: PDPK1

Interactor 2: HSP74 (P34932)
Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2)
Gene: HSPA4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 556 Hs			1 840
+	Hs
		182188 PDPK1_HUMAN (1-556): 0: 563: 100.00		HS105_HUMAN (1-840): 0: 938: 62.95
+	Hs
		681688 AKT1_HUMAN (46-410): 1.08e-141: 419: 31.35		HSP74_HUMAN (1-840): 0: 993: 100.00
+	Hs
		568562 KAPCA_HUMAN (40-391): 7.05e-139: 407: 31.53		HSP74_HUMAN (1-840): 0: 993: 100.00
+	Hs
		116975 SGK1_HUMAN (71-402): 1.58e-130: 389: 34.84		HSP74_HUMAN (1-840): 0: 993: 100.00
+	Hs
		850687 KS6A3_HUMAN (4-354): 3.18e-103: 328: 24.20		HS105_HUMAN (1-840): 0: 938: 62.95
+	Sc
		695399 PKH1_YEAST (80-361): 4.84e-80: 268: 46.28		HSP7F_YEAST (5-697): 5.7e-137: 424: 37.61
+	Sc
		695392 PKH3_YEAST (75-349): 7.67e-69: 240: 43.89		HSP7F_YEAST (5-697): 5.7e-137: 424: 37.61
+	Hs
		182076 PDPK1_HUMAN (1-556): 0: 563: 100.00		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		182080 PDPK1_HUMAN (1-556): 0: 563: 100.00		HSP76_HUMAN (587-690): 1.94e-16: 85.8: 22.86
+	Sc
		520590 YPK1_YEAST (73-366): 1.93e-60: 213: 38.46		HSP7F_YEAST (5-697): 5.7e-137: 424: 37.61
+	Sc
		579931 YPK2_YEAST (73-363): 1.72e-59: 211: 37.76		HSP7F_YEAST (5-697): 5.7e-137: 424: 37.61
+	Hs
		503528 AKT1_HUMAN (46-410): 1.08e-141: 419: 31.35		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		564016 AKT1_HUMAN (46-410): 1.08e-141: 419: 31.35		HSP76_HUMAN (587-690): 1.94e-16: 85.8: 22.86
+	Hs
		503439 KAPCG_HUMAN (70-391): 1.4e-137: 404: 32.61		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		503719 KS6A3_HUMAN (4-354): 3.18e-103: 328: 24.20		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		564041 KS6A3_HUMAN (4-354): 3.18e-103: 328: 24.20		HSP76_HUMAN (587-690): 1.94e-16: 85.8: 22.86