HitPredict

Interactor 1: KDM6A (O15550)
Lysine-specific demethylase 6A (EC 1.14.11.68) (Histone demethylase UTX) (Ubiquitously-transcribed TPR protein on the X chromosome) (Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein) ([histone H3]-trimethyl-L-lysine(27) demethylase 6A)
Gene: KDM6A

Interactor 2: SOX2 (P48431)
Transcription factor SOX-2
Gene: SOX2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	28794006, 35140242, 22801502
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0010468 - regulation of gene expression
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 1401 Hs			1 317
+	Hs
		183081 KDM6A_HUMAN (1-1401): 0: 1681: 100.00		SOX9_HUMAN (28-260): 2.6e-37: 140: 27.57
+	Hs
		183160 KDM6A_HUMAN (1-1401): 0: 1681: 100.00		SOX17_HUMAN (7-260): 1.35e-34: 132: 28.19
+	Hs
		183091 KDM6A_HUMAN (1-1401): 0: 1681: 100.00		SOX10_HUMAN (28-219): 8.75e-34: 130: 35.42
+	Hs
		183153 KDM6A_HUMAN (1-1401): 0: 1681: 100.00		SOX7_HUMAN (23-299): 8.76e-34: 129: 27.03
+	Hs
		183046 KDM6A_HUMAN (1-1401): 0: 1681: 100.00		SOX15_HUMAN (13-118): 1.78e-31: 119: 66.04
+	Mm
		818742 OGT1_MOUSE (166-609): 6.54e-46: 182: 13.63		SOX2_MOUSE (1-317): 8.01e-72: 226: 94.67
+	Hs
		818167 CTR9_HUMAN (173-542): 2.86e-18: 93.5: 10.97		SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00
+	Hs
		818581 CDC23_HUMAN (134-642): 8.91e-16: 84.6: 11.21		SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00
+	Hs
		165827 KDM6B_HUMAN (252-941): 3.78e-14: 80.1: 16.69		SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00
+	Mm
		1207351 OGT1_MOUSE (166-609): 6.54e-46: 182: 13.63		NSD2_MOUSE (10-255): 7.97e-34: 133: 11.16
+	Hs
		727823 CDC23_HUMAN (134-642): 8.91e-16: 84.6: 11.21		SOX5_HUMAN (2-127): 7.91e-43: 158: 41.27
+	Hs
		989535 CTR9_HUMAN (173-542): 2.86e-18: 93.5: 10.97		SOX4_HUMAN (9-289): 2.6e-33: 129: 26.69
+	Hs
		996719 CTR9_HUMAN (173-542): 2.86e-18: 93.5: 10.97		SSRP1_HUMAN (24-203): 1.77e-31: 125: 15.68
+	Hs
		165844 KDM6B_HUMAN (252-941): 3.78e-14: 80.1: 16.69		SSRP1_HUMAN (24-203): 1.77e-31: 125: 15.68