HitPredict

Interactor 1: KDM6A (O15550)
Lysine-specific demethylase 6A (EC 1.14.11.68) (Histone demethylase UTX) (Ubiquitously-transcribed TPR protein on the X chromosome) (Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein) ([histone H3]-trimethyl-L-lysine(27) demethylase 6A)
Gene: KDM6A

Interactor 2: KMT2A (Q03164)
Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
Gene: KMT2A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	24981860
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	JmjC~PHD
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0035097 - histone methyltransferase complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1401 Hs			1 3969
+	Hs
		174816 OGT1_HUMAN (166-609): 5.45e-46: 183: 13.63		KMT2A_HUMAN (1-3969): 0: 3187: 100.00
+	Hs
		975273 CTR9_HUMAN (173-542): 2.86e-18: 93.5: 10.97		KMT2A_HUMAN (1-3969): 0: 3187: 100.00
+	Hs
		672815 CDC27_HUMAN (96-315): 2.28e-11: 70.6: 22.75		KMT2A_HUMAN (1-3969): 0: 3187: 100.00
+	Hs
		183176 KDM6A_HUMAN (1-1401): 0: 1681: 100.00		KMT2B_HUMAN (3163-3969): 3.56e-127: 454: 36.71
+	Hs
		183120 KDM6A_HUMAN (1-1401): 0: 1681: 100.00		EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54
+	Hs
		183177 KDM6A_HUMAN (1-1401): 0: 1681: 100.00		SET1B_HUMAN (3529-3969): 1.64e-66: 254: 27.12
+	Hs
		165600 KDM6A_HUMAN (1-1401): 0: 1681: 100.00		SET1A_HUMAN (3695-3969): 8.18e-56: 218: 34.58
+	Hs
		183137 KDM6A_HUMAN (1-1401): 0: 1681: 100.00		KMT2C_HUMAN (384-1407): 6.81e-11: 71.4: 10.23
+	Hs
		152556 KDM6A_HUMAN (1-1401): 0: 1681: 100.00		KMT2D_HUMAN (11-1393): 8.17e-09: 64.4: 10.47
+	Hs
		150104 UTY_HUMAN (1-1393): 0: 1402: 65.41		KMT2C_HUMAN (384-1407): 6.81e-11: 71.4: 10.23
+	Hs
		150088 UTY_HUMAN (1-1393): 0: 1402: 65.41		KMT2D_HUMAN (11-1393): 8.17e-09: 64.4: 10.47
+	Hs
		174922 OGT1_HUMAN (166-609): 5.45e-46: 183: 13.63		EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54
+	Hs
		1080213 TTC28_HUMAN (63-622): 2.38e-33: 143: 12.99		EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54
+	Dm
		114488 M9PCJ7_DROME (176-524): 4.06e-42: 170: 42.55		TRR_DROME (3623-3969): 9.32e-71: 268: 31.59
+	Hs
		165599 OGT1_HUMAN (166-609): 5.45e-46: 183: 13.63		SET1A_HUMAN (3695-3969): 8.18e-56: 218: 34.58
+	Mm
		1207351 OGT1_MOUSE (166-609): 6.54e-46: 182: 13.63		NSD2_MOUSE (3752-3968): 6.91e-55: 215: 27.68
+	Dm
		114503 M9PCJ7_DROME (176-524): 4.06e-42: 170: 42.55		Q9W1H0_DROME (1299-1688): 3.62e-57: 223: 18.30
+	Hs
		203808 CDC23_HUMAN (134-642): 8.91e-16: 84.6: 11.21		SUV91_HUMAN (3630-3968): 1.07e-83: 284: 18.97
+	Sc
		542134 CYC8_YEAST (250-1073): 2.27e-33: 142: 12.84		SET2_YEAST (3811-3968): 1.56e-56: 214: 29.56
+	Hs
		175053 OGT1_HUMAN (166-609): 5.45e-46: 183: 13.63		KMT2C_HUMAN (384-1407): 6.81e-11: 71.4: 10.23