HitPredict

Interactor 1: KDM6A (O15550)
Lysine-specific demethylase 6A (EC 1.14.11.68) (Histone demethylase UTX) (Ubiquitously-transcribed TPR protein on the X chromosome) (Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein) ([histone H3]-trimethyl-L-lysine(27) demethylase 6A)
Gene: KDM6A

Interactor 2: RBBP5 (Q15291)
Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3)
Gene: RBBP5

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.969

Property	Details
Experiments	31076518, 24981860, 33961781, 23508102, 29785026, 17761849, 17500065, 17825402, 17178841
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	TPR_16~WD40
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0035097 - histone methyltransferase complex GO:0044666 - MLL3/4 complex
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1401 Hs			1 538
+	Hs
		150102 UTY_HUMAN (1-1393): 0: 1402: 65.41		RBBP5_HUMAN (1-538): 2.69e-137: 410: 100.00
+	Hs
		183146 KDM6A_HUMAN (1-1401): 0: 1681: 100.00		FBXW7_HUMAN (279-521): 2.8e-16: 83.9: 10.56
+	Hs
		183095 KDM6A_HUMAN (1-1401): 0: 1681: 100.00		WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41
+	Hs
		99745 F5H5V6_HUMAN (1-1401): 0: 1476: 75.94		WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41
+	Hs
		150096 UTY_HUMAN (1-1393): 0: 1402: 65.41		WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41
+	Ce
		1089275 JMJ31_CAEEL (435-1390): 0: 767: 21.01		WDR51_CAEEL (140-424): 4.13e-47: 170: 13.29
+	Hs
		174908 OGT1_HUMAN (166-609): 5.45e-46: 183: 13.63		RBBP5_HUMAN (1-538): 2.69e-137: 410: 100.00
+	Mm
		1129461 KDM6B_MOUSE (336-979): 3.39e-20: 100: 16.72		RBBP5_MOUSE (1-538): 9.56e-137: 408: 99.07
+	Hs
		165853 KDM6B_HUMAN (252-941): 3.78e-14: 80.1: 16.69		RBBP5_HUMAN (1-538): 2.69e-137: 410: 100.00
+	Dm
		114497 M9PCJ7_DROME (176-524): 4.06e-42: 170: 42.55		RBBP5_DROME (1-494): 3.54e-103: 320: 65.79
+	Hs
		672838 CDC27_HUMAN (96-315): 2.28e-11: 70.6: 22.75		RBBP5_HUMAN (1-538): 2.69e-137: 410: 100.00
+	Ca
		483035 Q5ADP3_CANAL (273-951): 5.77e-24: 112: 12.99		TUP1_CANAL (100-402): 3.81e-53: 190: 16.10
+	Sp
		224208 CYC8_SCHPO (236-950): 7.13e-56: 214: 14.54		TUP12_SCHPO (226-339): 4.64e-10: 64.3: 18.33
+	Sp
		224207 CYC8_SCHPO (236-950): 7.13e-56: 214: 14.54		TUP11_SCHPO (2-58): 7.11e-09: 60.4: 14.04
+	Dm
		114491 M9PCJ7_DROME (176-524): 4.06e-42: 170: 42.55		WDS_DROME (250-438): 1.02e-21: 98.5: 10.82
+	Hs
		174768 OGT1_HUMAN (166-609): 5.45e-46: 183: 13.63		WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41
+	Hs
		165835 KDM6B_HUMAN (252-941): 3.78e-14: 80.1: 16.69		WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41
+	Hs
		672800 CDC27_HUMAN (96-315): 2.28e-11: 70.6: 22.75		WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41