HitPredict

Interactor 1: KDM6A (O15550)
Lysine-specific demethylase 6A (EC 1.14.11.68) (Histone demethylase UTX) (Ubiquitously-transcribed TPR protein on the X chromosome) (Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein) ([histone H3]-trimethyl-L-lysine(27) demethylase 6A)
Gene: KDM6A

Interactor 2: ASH2L (Q9UBL3)
Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein)
Gene: ASH2L

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.754

Property	Details
Experiments	31076518, 24981860, 34079125, 33961781, 23508102, 37974198, 20305087, 29785026, 17761849, 17825402, 17178841
Identification Methods	affinity chromatography technology, proximity labelling technology, anti bait coimmunoprecipitation, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0035097 - histone methyltransferase complex GO:0044666 - MLL3/4 complex GO:0046872 - metal ion binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1401 Hs			1 628
+	Hs
		150110 UTY_HUMAN (1-1393): 0: 1402: 65.41		ASH2L_HUMAN (1-628): 0: 790: 100.00
+	Hs
		183162 KDM6A_HUMAN (1-1401): 0: 1681: 100.00		CSR2B_HUMAN (61-327): 3.08e-65: 230: 17.75
+	Hs
		175277 OGT1_HUMAN (166-609): 5.45e-46: 183: 13.63		ASH2L_HUMAN (1-628): 0: 790: 100.00
+	Hs
		165879 KDM6B_HUMAN (252-941): 3.78e-14: 80.1: 16.69		ASH2L_HUMAN (1-628): 0: 790: 100.00
+	Hs
		672910 CDC27_HUMAN (96-315): 2.28e-11: 70.6: 22.75		ASH2L_HUMAN (1-628): 0: 790: 100.00
+	Dm
		114489 M9PCJ7_DROME (176-524): 4.06e-42: 170: 42.55		ASH2_DROME (87-621): 0: 541: 48.07
+	Hs
		962156 SKI3_HUMAN (291-454): 3.78e-12: 73.4: 16.37		HNRPU_HUMAN (301-600): 3.43e-52: 194: 20.74