HitPredict

Interactor 1: MEFV (O15553)
Pyrin (Marenostrin)
Gene: MEFV

Interactor 2: CASP1 (P29466)
Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10]
Gene: CASP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.80 0.60 0.694

The method score is based on:

Property Details
Experiments 16785446, 17431422, 16037825, 18577712
Identification Methods pull down, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, affinity chromatography technology, protease assay
Interaction Type physical association, cleavage reaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0002221 - pattern recognition receptor signaling pathway
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005874 - microtubule
GO:0032731 - positive regulation of interleukin-1 beta production
and 3 others

more...
Homologous interactions 3

Homologous interactions

Color coding for hit scores

1 781
Hs

1 404
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024