HitPredict

Interactor 1: STIP1 (O16259)
Stress-induced-phosphoprotein 1 (CeSTI1) (STI1) (Hsc70/Hsp90-organizing protein) (CeHop) (Hop)
Gene: sti-1

Interactor 2: HSP1 (P09446)
Heat shock protein hsp-1 (Heat shock 70 kDa protein A)
Gene: hsp-1

Species: Caenorhabditis elegans

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.639

Property	Details
Experiments	19467242, 19559711
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation, surface plasmon resonance
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0008340 - determination of adult lifespan GO:0009408 - response to heat
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 320 Ce			1 640
+	Hs
		564151 SGTB_HUMAN (4-126): 2.7e-24: 102: 27.64		HSP76_HUMAN (2-640): 0: 942: 77.22
+	Mm
		926144 SGTA_MOUSE (2-126): 1.48e-22: 97.5: 28.80		HSP7C_MOUSE (1-614): 0: 942: 86.32
+	Hs
		213468 SGTA_HUMAN (2-126): 2.87e-22: 96.7: 30.40		HSP7C_HUMAN (1-614): 0: 942: 86.32
+	Hs
		684439 STIP1_HUMAN (2-127): 1.1e-16: 82.5: 19.84		HS71L_HUMAN (2-640): 0: 953: 80.60
+	Hs
		564188 RPAP3_HUMAN (3-126): 1.74e-17: 84.8: 20.97		HSP76_HUMAN (2-640): 0: 942: 77.22
+	Hs
		503534 STIP1_HUMAN (2-127): 1.1e-16: 82.5: 19.84		HSP7C_HUMAN (1-614): 0: 942: 86.32
+	Hs
		564017 STIP1_HUMAN (2-127): 1.1e-16: 82.5: 19.84		HSP76_HUMAN (2-640): 0: 942: 77.22
+	Hs
		503738 PPP5_HUMAN (3-145): 1.18e-16: 82.1: 22.92		HSP7C_HUMAN (1-614): 0: 942: 86.32
+	Hs
		564043 PPP5_HUMAN (3-145): 1.18e-16: 82.1: 22.92		HSP76_HUMAN (2-640): 0: 942: 77.22
+	Mm
		926131 PPP5_MOUSE (3-145): 2.47e-16: 81.3: 21.53		HSP7C_MOUSE (1-614): 0: 942: 86.32
+	Dm
		505095 Q9VJD4_DROME (5-133): 1.54e-21: 94.8: 21.71		HSP7D_DROME (1-613): 0: 927: 84.18
+	At
		1338008 HSOP1_ARATH (5-111): 3.71e-16: 80.9: 19.63		HS704_ARATH (2-640): 0: 937: 76.01
+	Hs
		174578 OGT1_HUMAN (5-144): 2.15e-14: 75.9: 15.71		HSP7C_HUMAN (1-614): 0: 942: 86.32
+	Hs
		504631 DNJC7_HUMAN (11-245): 4.3e-14: 74.3: 26.85		HSP7C_HUMAN (1-614): 0: 942: 86.32
+	Hs
		483776 STIP1_HUMAN (2-127): 1.1e-16: 82.5: 19.84		HS71B_HUMAN (1-640): 0: 933: 81.46
+	Hs
		684557 STIP1_HUMAN (2-127): 1.1e-16: 82.5: 19.84		HSP72_HUMAN (2-640): 0: 925: 81.12
+	Hs
		483768 DNJC7_HUMAN (11-245): 4.3e-14: 74.3: 26.85		HS71A_HUMAN (1-640): 0: 933: 81.46
+	Hs
		483801 DNJC7_HUMAN (11-245): 4.3e-14: 74.3: 26.85		HS71B_HUMAN (1-640): 0: 933: 81.46
+	Dm
		505103 Q9VPN5_DROME (2-139): 5.25e-16: 80.1: 18.12		HSP7D_DROME (1-613): 0: 927: 84.18
+	Hs
		871541 SPAG1_HUMAN (5-136): 7.58e-16: 80.1: 19.70		HSP72_HUMAN (2-640): 0: 925: 81.12