HitPredict

Interactor 1: PRS4 (O16368)
Probable 26S proteasome regulatory subunit 4
Gene: rpt-2

Interactor 2: NHR6 (P41829)
Nuclear hormone receptor family member nhr-6 (Nuclear receptor subfamily 4 group A member 5) (Steroid hormone receptor family member cnr8)
Gene: nhr-6

Species: Caenorhabditis elegans

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.635

Property	Details
Experiments	12679813, 14704431, 11559592
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 443 Ce			1 619
+	Ce
		784587 PRS8_CAEEL (45-443): 8.61e-123: 364: 43.67		NHR6_CAEEL (1-619): 0: 557: 100.00
+	Hs
		369310 PRS4_HUMAN (28-443): 6.72e-134: 394: 85.34		ESR1_HUMAN (86-609): 1.48e-134: 408: 18.39
+	Hs
		369311 PRS8_HUMAN (47-443): 9.9e-124: 367: 43.89		ESR1_HUMAN (86-609): 1.48e-134: 408: 18.39
+	Hs
		369327 PRS10_HUMAN (67-442): 3.54e-123: 364: 38.56		ESR1_HUMAN (86-609): 1.48e-134: 408: 18.39
+	Hs
		369145 PRS6B_HUMAN (53-438): 2.75e-120: 358: 46.63		ESR1_HUMAN (86-609): 1.48e-134: 408: 18.39
+	Rn
		411261 PRS8_RAT (47-443): 9.9e-124: 367: 43.89		ESR1_RAT (86-604): 9.07e-126: 385: 17.51
+	Hs
		587150 PRS8_HUMAN (47-443): 9.9e-124: 367: 43.89		RXRA_HUMAN (161-592): 2.2e-123: 374: 22.71
+	Hs
		906889 PRS4_HUMAN (28-443): 6.72e-134: 394: 85.34		ESR2_HUMAN (120-608): 2.36e-111: 346: 16.76
+	Hs
		611411 PRS4_HUMAN (28-443): 6.72e-134: 394: 85.34		NR4A1_HUMAN (119-579): 7.07e-110: 344: 28.45
+	Hs
		907111 PRS8_HUMAN (47-443): 9.9e-124: 367: 43.89		ESR2_HUMAN (120-608): 2.36e-111: 346: 16.76
+	Hs
		611412 PRS8_HUMAN (47-443): 9.9e-124: 367: 43.89		NR4A1_HUMAN (119-579): 7.07e-110: 344: 28.45
+	Hs
		913328 PRS10_HUMAN (67-442): 3.54e-123: 364: 38.56		ESR2_HUMAN (120-608): 2.36e-111: 346: 16.76
+	Hs
		500362 PRS8_HUMAN (47-443): 9.9e-124: 367: 43.89		RARB_HUMAN (198-609): 7.66e-110: 339: 20.23
+	Hs
		740491 PRS4_HUMAN (28-443): 6.72e-134: 394: 85.34		PPARG_HUMAN (133-587): 2.86e-97: 308: 19.53
+	Hs
		906980 PRS8_HUMAN (47-443): 9.9e-124: 367: 43.89		ERR3_HUMAN (190-587): 2.08e-105: 327: 19.72
+	Hs
		907027 PRS8_HUMAN (47-443): 9.9e-124: 367: 43.89		HNF4G_HUMAN (257-585): 8.74e-104: 322: 18.62
+	Hs
		487934 PRS8_HUMAN (47-443): 9.9e-124: 367: 43.89		RARA_HUMAN (201-589): 9.38e-103: 321: 20.80
+	Hs
		530791 PRS8_HUMAN (47-443): 9.9e-124: 367: 43.89		RARG_HUMAN (185-608): 3.16e-102: 319: 20.91
+	Hs
		907008 PRS8_HUMAN (47-443): 9.9e-124: 367: 43.89		NR1H3_HUMAN (184-589): 1.47e-96: 304: 17.30
+	Hs
		906997 PRS8_HUMAN (47-443): 9.9e-124: 367: 43.89		PPARD_HUMAN (224-568): 6.22e-89: 284: 22.81