HitPredict

Interactor 1: ORC1 (O16810)
Origin recognition complex subunit 1 (DmORC1)
Gene: ORC1

Interactor 2: ORC5 (Q24169)
Origin recognition complex subunit 5
Gene: ORC5

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.893

Property	Details
Experiments	24137536, 25762138, 29899147, 32848132
Identification Methods	affinity chromatography technology, x-ray crystallography, pull down
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	AAA~AAA_16, AAA_16~AAA_lid_10
Common GO terms	GO:0003688 - DNA replication origin binding GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005664 - nuclear origin of replication recognition complex GO:0006270 - DNA replication initiation and 1 others more... GO:0016887 - ATP hydrolysis activity
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 924 Dm			1 460
+	Dm
		184170 ORC1_DROME (1-924): 0: 673: 100.00		Q9VSM9_DROME (4-223): 2.55e-52: 188: 15.04
+	Hs
		217257 ORC1_HUMAN (45-920): 8.52e-121: 389: 30.46		ORC5_HUMAN (7-460): 1.54e-148: 431: 34.69
+	Dm
		184172 ORC1_DROME (1-924): 0: 673: 100.00		Q9W102_DROME (27-183): 2.47e-18: 89: 10.92
+	Hs
		217275 CDC6_HUMAN (407-923): 6.79e-81: 274: 23.88		ORC5_HUMAN (7-460): 1.54e-148: 431: 34.69
+	Hs
		217213 ORC4_HUMAN (532-918): 1.08e-78: 264: 16.71		ORC5_HUMAN (7-460): 1.54e-148: 431: 34.69
+	At
		1150968 ORC1B_ARATH (135-923): 3e-102: 339: 25.09		ORC5_ARATH (6-457): 3.06e-110: 337: 22.14
+	Sc
		842056 ORC1_YEAST (378-923): 8.54e-78: 274: 22.89		ORC5_YEAST (10-458): 3.66e-115: 348: 21.93
+	Hs
		1033398 ORC1_HUMAN (45-920): 8.52e-121: 389: 30.46		CDC6_HUMAN (4-246): 4.03e-65: 221: 17.60
+	Sp
		195259 ORC1_SCHPO (441-923): 9.63e-78: 269: 33.60		ORC5_SCHPO (4-456): 1.66e-111: 338: 23.90
+	Hs
		1033375 ORC1_HUMAN (45-920): 8.52e-121: 389: 30.46		ORC1_HUMAN (5-214): 2.67e-53: 193: 13.12
+	Hs
		217798 ORC1_HUMAN (45-920): 8.52e-121: 389: 30.46		ORC4_HUMAN (2-255): 3.7e-42: 156: 16.00
+	Hs
		1306109 CDC6_HUMAN (407-923): 6.79e-81: 274: 23.88		CDC6_HUMAN (4-246): 4.03e-65: 221: 17.60
+	Sp
		783438 ORC1_SCHPO (441-923): 9.63e-78: 269: 33.60		CDC18_SCHPO (6-231): 1.98e-54: 192: 13.68
+	Sp
		872882 ORC1_SCHPO (441-923): 9.63e-78: 269: 33.60		ORC1_SCHPO (5-247): 4.52e-53: 191: 15.75
+	Sc
		872778 ORC1_YEAST (378-923): 8.54e-78: 274: 22.89		ORC1_YEAST (10-199): 4.47e-43: 164: 14.93
+	Sc
		447805 ORC1_YEAST (378-923): 8.54e-78: 274: 22.89		CDC6_YEAST (5-224): 7.22e-36: 140: 12.78
+	Sp
		872885 ORC1_SCHPO (441-923): 9.63e-78: 269: 33.60		ORC4_SCHPO (6-288): 6.35e-17: 85.6: 11.69