HitPredict

Interactor 1: ORC1 (O16810)
Origin recognition complex subunit 1 (DmORC1)
Gene: ORC1

Interactor 2: Q7K2L1 (Q7K2L1)
Origin recognition complex subunit 3
Gene: Orc3

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.893

Property	Details
Experiments	24137536, 29899147, 25762138, 32848132
Identification Methods	affinity chromatography technology, pull down, x-ray crystallography
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	AAA~ORC_WH_C
Common GO terms	GO:0003688 - DNA replication origin binding GO:0005634 - nucleus GO:0005664 - nuclear origin of replication recognition complex GO:0006270 - DNA replication initiation
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 924 Dm			1 721
+	Hs
		1033405 ORC1_HUMAN (45-920): 8.52e-121: 389: 30.46		ORC3_HUMAN (4-721): 0: 721: 32.27
+	Dm
		1179277 Q9VSM9_DROME (318-923): 3.62e-63: 228: 17.99		Q7K2L1_DROME (1-721): 0: 873: 100.00
+	Dm
		1179280 Q9W102_DROME (543-910): 1.7e-42: 163: 16.06		Q7K2L1_DROME (1-721): 0: 873: 100.00
+	Hs
		1306117 CDC6_HUMAN (407-923): 6.79e-81: 274: 23.88		ORC3_HUMAN (4-721): 0: 721: 32.27
+	At
		1150653 ORC1A_ARATH (134-923): 5.38e-119: 383: 25.06		ORC3_ARATH (19-721): 0: 606: 21.57
+	Hs
		217839 ORC4_HUMAN (532-918): 1.08e-78: 264: 16.71		ORC3_HUMAN (4-721): 0: 721: 32.27
+	At
		1150652 ORC4_ARATH (545-910): 1.57e-62: 219: 19.80		ORC3_ARATH (19-721): 0: 606: 21.57
+	Sp
		872884 ORC1_SCHPO (441-923): 9.63e-78: 269: 33.60		ORC3_SCHPO (56-721): 1.32e-144: 440: 19.01
+	Sp
		783441 CDC18_SCHPO (403-923): 4.11e-64: 228: 20.83		ORC3_SCHPO (56-721): 1.32e-144: 440: 19.01
+	Sp
		1013457 ORC4_SCHPO (215-893): 4.35e-60: 224: 14.23		ORC3_SCHPO (56-721): 1.32e-144: 440: 19.01