HitPredict

Interactor 1: FOXO (O16850)
Forkhead box protein O (FOXO) (Abnormal dauer formation protein 16)
Gene: daf-16

Interactor 2: CBP1 (P34545)
Protein cbp-1 (EC 2.3.1.48)
Gene: cbp-1

Species: Caenorhabditis elegans

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	10973497, 23028355
Identification Methods	two hybrid, enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0006355 - regulation of DNA-templated transcription GO:0043065 - positive regulation of apoptotic process GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 541 Ce			1 2017
+	Mm
		101473 FOXO3_MOUSE (121-369): 1.61e-51: 188: 42.97		F8VPR5_MOUSE (4-1972): 0: 858: 27.06
+	Mm
		799606 FOXO4_MOUSE (133-385): 5.7e-54: 192: 38.76		CBP_MOUSE (4-1972): 0: 840: 26.67
+	Ce
		184246 FOXO_CAEEL (1-541): 0: 751: 100.00		NU301_CAEEL (77-1018): 3.9e-48: 192: 11.24
+	Hs
		877735 FOXA1_HUMAN (103-399): 1.04e-60: 209: 18.77		BRD3_HUMAN (566-973): 1.27e-45: 179: 17.28
+	Hs
		170350 FOXI1_HUMAN (115-361): 3.31e-44: 162: 22.14		TIF1A_HUMAN (400-1011): 1.4e-44: 179: 11.56
+	Hs
		178982 FOXP2_HUMAN (127-378): 3.36e-44: 168: 20.47		PHIP_HUMAN (810-972): 3.82e-40: 166: 30.54
+	Hs
		206831 FOXO3_HUMAN (121-369): 1.73e-51: 188: 42.17		EP300_HUMAN (20-436): 5.06e-09: 63.9: 10.75
+	Hs
		206847 FOXO3_HUMAN (121-369): 1.73e-51: 188: 42.17		CBP_HUMAN (142-686): 8.75e-09: 63.2: 9.89
+	Mm
		70946 FOXO3_MOUSE (121-369): 1.61e-51: 188: 42.97		EP300_MOUSE (172-698): 9.27e-09: 63.2: 8.04
+	Hs
		964170 FOXK2_HUMAN (122-391): 5.63e-49: 181: 21.46		EP300_HUMAN (20-436): 5.06e-09: 63.9: 10.75
+	Hs
		964171 FOXK2_HUMAN (122-391): 5.63e-49: 181: 21.46		BPTF_HUMAN (1680-2015): 6.9e-09: 63.6: 8.54
+	Hs
		270822 FOXH1_HUMAN (144-437): 2.35e-51: 181: 19.57		CBP_HUMAN (142-686): 8.75e-09: 63.2: 9.89
+	Hs
		998614 FOXO1_HUMAN (117-442): 8.5e-48: 178: 33.23		EP300_HUMAN (20-436): 5.06e-09: 63.9: 10.75
+	Hs
		1016224 FOXO1_HUMAN (117-442): 8.5e-48: 178: 33.23		CBP_HUMAN (142-686): 8.75e-09: 63.2: 9.89
+	Hs
		958169 FOXO4_HUMAN (142-385): 1.1e-46: 172: 37.90		CBP_HUMAN (142-686): 8.75e-09: 63.2: 9.89
+	Hs
		993309 FOXM1_HUMAN (161-428): 4.93e-45: 171: 20.70		EP300_HUMAN (20-436): 5.06e-09: 63.9: 10.75
+	Hs
		993334 FOXM1_HUMAN (161-428): 4.93e-45: 171: 20.70		CBP_HUMAN (142-686): 8.75e-09: 63.2: 9.89
+	Hs
		877605 FOXG1_HUMAN (132-370): 2.71e-43: 162: 21.55		EP300_HUMAN (20-436): 5.06e-09: 63.9: 10.75
+	Hs
		998627 FOXI1_HUMAN (115-361): 3.31e-44: 162: 22.14		EP300_HUMAN (20-436): 5.06e-09: 63.9: 10.75
+	Hs
		1021242 FOXI1_HUMAN (115-361): 3.31e-44: 162: 22.14		CBP_HUMAN (142-686): 8.75e-09: 63.2: 9.89