HitPredict

Interactor 1: FOXO (O16850)
Forkhead box protein O (FOXO) (Abnormal dauer formation protein 16)
Gene: daf-16

Interactor 2: VRK1 (Q19848)
Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1)
Gene: vrk-1

Species: Caenorhabditis elegans

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	26154057
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 541 Ce			1 610
+	Ce
		184240 FOXO_CAEEL (1-541): 0: 751: 100.00		KIN20_CAEEL (1-322): 4.49e-105: 328: 22.94
+	Hs
		877852 FOXA1_HUMAN (103-399): 1.04e-60: 209: 18.77		VRK1_HUMAN (4-383): 1.97e-136: 405: 30.95
+	Dm
		1213370 FOXO_DROME (151-371): 8.5e-54: 194: 46.61		AKT1_DROME (21-372): 4.53e-114: 355: 14.44
+	Hs
		821956 FOXA1_HUMAN (103-399): 1.04e-60: 209: 18.77		KC1A_HUMAN (19-362): 5.04e-109: 332: 19.37
+	Hs
		206806 FOXO3_HUMAN (121-369): 1.73e-51: 188: 42.17		AKT1_HUMAN (6-349): 6.77e-112: 345: 14.73
+	Rn
		88534 D3ZBQ1_RAT (120-369): 3.21e-50: 185: 42.40		AKT1_RAT (6-349): 3.37e-112: 345: 14.73
+	Hs
		681813 FOXO1_HUMAN (117-442): 8.5e-48: 178: 33.23		AKT1_HUMAN (6-349): 6.77e-112: 345: 14.73
+	Mm
		682129 FOXO1_MOUSE (121-442): 1.28e-47: 177: 36.09		AKT1_MOUSE (6-349): 2.69e-112: 346: 14.73
+	Dm
		539758 FKH_DROME (105-419): 9.74e-45: 167: 19.45		AKT1_DROME (21-372): 4.53e-114: 355: 14.44
+	Hs
		681791 FOXO4_HUMAN (142-385): 1.1e-46: 172: 37.90		AKT1_HUMAN (6-349): 6.77e-112: 345: 14.73
+	Hs
		178954 FOXP2_HUMAN (127-378): 3.36e-44: 168: 20.47		KC1E_HUMAN (27-449): 3.67e-109: 336: 17.67
+	Hs
		687045 FOXN2_HUMAN (128-401): 1.44e-47: 173: 18.79		KS6A3_HUMAN (5-363): 1.33e-79: 268: 13.28
+	Hs
		1217347 FOXP1_HUMAN (179-266): 3.81e-11: 67.8: 40.91		VRK3_HUMAN (48-266): 3.09e-21: 99: 29.91