HitPredict

Interactor 1: FOXO (O16850)
Forkhead box protein O (FOXO) (Abnormal dauer formation protein 16)
Gene: daf-16

Interactor 2: SIR2 (Q21921)
NAD-dependent protein deacetylase sir-2.1 (EC 2.3.1.286) (Protein sir-2.1) (Regulatory protein SIR2 homolog 1)
Gene: sir-2.1

Species: Caenorhabditis elegans

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.62 0.60 0.612

The method score is based on:

Property Details
Experiments 16777605, 16860373
Identification Methods affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0008340 - determination of adult lifespan
GO:0010468 - regulation of gene expression
GO:0010628 - positive regulation of gene expression
and 3 others

more...
Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 541
Ce

1 607
+ Ce
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Sc

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024