HitPredict

Interactor 1: EYA1 (O17670)
Eyes absent homolog 1 (EC 3.1.3.48)
Gene: eya-1

Interactor 2: HM34 (Q94165)
Homeobox protein ceh-34
Gene: ceh-34

Species: Caenorhabditis elegans

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.695

Property	Details
Experiments	19123269, 20713707, 23791784, 19427847
Identification Methods	two hybrid, affinity chromatography technology, two hybrid array, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0006355 - regulation of DNA-templated transcription GO:0007501 - mesodermal cell fate specification GO:1904747 - positive regulation of apoptotic process involved in development
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 503 Ce			1 256
+	Ce
		184785 EYA1_CAEEL (1-503): 0: 520: 100.00		HM33_CAEEL (4-250): 2.26e-73: 226: 38.40
+	Mm
		956578 EYA3_MOUSE (3-500): 2.92e-169: 489: 22.66		SIX1_MOUSE (10-255): 1.52e-78: 240: 43.15
+	Hs
		118562 EYA2_HUMAN (23-497): 3.99e-168: 487: 22.20		SIX1_HUMAN (10-255): 9.74e-79: 240: 43.15
+	Hs
		118611 EYA2_HUMAN (23-497): 3.99e-168: 487: 22.20		SIX2_HUMAN (10-230): 8.05e-78: 238: 46.46
+	Hs
		118619 EYA2_HUMAN (23-497): 3.99e-168: 487: 22.20		SIX4_HUMAN (13-256): 2.76e-70: 231: 41.87
+	Mm
		139225 EYA2_MOUSE (13-497): 2.79e-164: 477: 22.12		SIX4_MOUSE (13-256): 4.75e-73: 238: 41.46
+	Hs
		1074456 EYA1_HUMAN (26-497): 3.33e-158: 464: 21.97		SIX1_HUMAN (10-255): 9.74e-79: 240: 43.15
+	Hs
		1304309 EYA3_HUMAN (3-500): 1.75e-159: 466: 23.30		SIX2_HUMAN (10-230): 8.05e-78: 238: 46.46
+	Hs
		1304296 EYA1_HUMAN (26-497): 3.33e-158: 464: 21.97		SIX2_HUMAN (10-230): 8.05e-78: 238: 46.46
+	Mm
		936192 EYA3_MOUSE (3-500): 2.92e-169: 489: 22.66		SIX5_MOUSE (11-252): 8.2e-63: 210: 38.15
+	Mm
		956886 EYA1_MOUSE (26-497): 1.47e-155: 457: 21.77		SIX2_MOUSE (10-236): 1.06e-78: 241: 44.98
+	Mm
		956885 EYA1_MOUSE (26-497): 1.47e-155: 457: 21.77		SIX1_MOUSE (10-255): 1.52e-78: 240: 43.15
+	Ce
		184703 EYA1_CAEEL (1-503): 0: 520: 100.00		HM35_CAEEL (10-211): 4.28e-53: 176: 33.33
+	Hs
		1304297 EYA1_HUMAN (26-497): 3.33e-158: 464: 21.97		SIX4_HUMAN (13-256): 2.76e-70: 231: 41.87
+	Mm
		956884 EYA1_MOUSE (26-497): 1.47e-155: 457: 21.77		SIX4_MOUSE (13-256): 4.75e-73: 238: 41.46
+	Hs
		318622 EYA4_HUMAN (25-497): 3.6e-151: 447: 22.67		SIX1_HUMAN (10-255): 9.74e-79: 240: 43.15
+	Hs
		1230645 EYA3_HUMAN (3-500): 1.75e-159: 466: 23.30		SIX5_HUMAN (12-252): 1.6e-63: 213: 37.90
+	Hs
		1230644 EYA1_HUMAN (26-497): 3.33e-158: 464: 21.97		SIX5_HUMAN (12-252): 1.6e-63: 213: 37.90
+	Mm
		956887 EYA1_MOUSE (26-497): 1.47e-155: 457: 21.77		SIX3_MOUSE (10-235): 3e-69: 218: 39.74
+	Mm
		936193 EYA1_MOUSE (26-497): 1.47e-155: 457: 21.77		SIX5_MOUSE (11-252): 8.2e-63: 210: 38.15