HitPredict

Interactor 1: NHR79 (O18141)
Nuclear hormone receptor family member nhr-79
Gene: nhr-79

Interactor 2: NHR49 (O45666)
Nuclear hormone receptor family member nhr-49
Gene: nhr-49

Species: Caenorhabditis elegans

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.852

Property	Details
Experiments	23791784, 22511885, 14704431
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Hormone_recep~Hormone_recep, Hormone_recep~zf-C4, zf-C4~zf-C4
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005634 - nucleus GO:0008270 - zinc ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 463 Ce			1 501
+	Ce
		220328 NHR22_CAEEL (3-462): 1.62e-96: 303: 32.78		NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00
+	Ce
		220352 NHR13_CAEEL (18-461): 7.3e-86: 271: 24.89		NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00
+	Ce
		219559 O44577_CAEEL (1-463): 3.04e-84: 267: 53.13		NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00
+	Ce
		109537 NHR66_CAEEL (6-462): 9.56e-77: 256: 17.14		NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00
+	Ce
		220319 NHR49_CAEEL (2-457): 3.31e-79: 256: 17.07		NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00
+	Ce
		220327 NHR20_CAEEL (2-461): 6.07e-79: 254: 24.68		NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00
+	Hs
		782501 NR2C2_HUMAN (4-462): 5.34e-92: 292: 14.84		HNF4A_HUMAN (5-495): 7.48e-107: 328: 27.80
+	Hs
		659697 NR2C2_HUMAN (4-462): 5.34e-92: 292: 14.84		RXRB_HUMAN (33-423): 4.66e-102: 318: 28.65
+	Hs
		369177 NR2C2_HUMAN (4-462): 5.34e-92: 292: 14.84		ESR1_HUMAN (14-467): 1.59e-96: 305: 19.87
+	Ce
		999494 NHR22_CAEEL (3-462): 1.62e-96: 303: 32.78		NHR5_CAEEL (7-419): 1.13e-85: 279: 26.97
+	Hs
		622775 NR2C2_HUMAN (4-462): 5.34e-92: 292: 14.84		COT2_HUMAN (29-420): 7.47e-92: 287: 25.26
+	Ce
		137568 NHR4_CAEEL (5-456): 1.21e-85: 272: 19.12		NHR62_CAEEL (35-420): 4.05e-92: 291: 23.19
+	Ce
		220326 NHR49_CAEEL (2-457): 3.31e-79: 256: 17.07		NHR19_CAEEL (33-421): 6.6e-96: 300: 22.84
+	Ce
		220027 NHR4_CAEEL (5-456): 1.21e-85: 272: 19.12		NHR61_CAEEL (35-418): 3.7e-90: 283: 21.63
+	Ce
		106935 H2KZA1_CAEEL (4-459): 1.64e-78: 257: 16.78		NH114_CAEEL (21-426): 1.22e-93: 292: 24.16
+	Ce
		106951 NHR49_CAEEL (2-457): 3.31e-79: 256: 17.07		NH114_CAEEL (21-426): 1.22e-93: 292: 24.16
+	Ce
		220347 NHR49_CAEEL (2-457): 3.31e-79: 256: 17.07		Q95Y05_CAEEL (5-420): 2.38e-87: 276: 24.31
+	Ce
		220324 NHR49_CAEEL (2-457): 3.31e-79: 256: 17.07		P90822_CAEEL (31-420): 3.86e-29: 120: 25.98
+	Ce
		220343 NHR49_CAEEL (2-457): 3.31e-79: 256: 17.07		Q86PI8_CAEEL (35-113): 6.47e-29: 117: 59.49
+	Ce
		220349 NHR49_CAEEL (2-457): 3.31e-79: 256: 17.07		NHR71_CAEEL (32-417): 4.8e-27: 116: 24.05