HitPredict

Interactor 1: P5CR (O25773)
Pyrroline-5-carboxylate reductase (P5C reductase) (P5CR) (EC 1.5.1.2) (PCA reductase)
Gene: proC

Interactor 2: P5CR (O25773)
Pyrroline-5-carboxylate reductase (P5C reductase) (P5CR) (EC 1.5.1.2) (PCA reductase)
Gene: proC

Species: Helicobacter pylori 26695

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	11196647
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	F420_oxidored~F420_oxidored, F420_oxidored~P5CR_dimer, P5CR_dimer~P5CR_dimer
Common GO terms	GO:0004735 - pyrroline-5-carboxylate reductase activity GO:0005737 - cytoplasm GO:0055129 - L-proline biosynthetic process
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 257 Hp			1 257
+	Hs
		1286327 P5CR2_HUMAN (4-256): 1.45e-95: 285: 26.49		P5CR2_HUMAN (4-256): 1.45e-95: 285: 26.49
+	Hs
		687171 P5CR1_HUMAN (4-256): 6.27e-96: 285: 24.25		P5CR1_HUMAN (4-256): 6.27e-96: 285: 24.25
+	Hs
		687258 P5CR2_HUMAN (4-256): 1.45e-95: 285: 26.49		P5CR1_HUMAN (4-256): 6.27e-96: 285: 24.25
+	Hs
		1121421 P5CR2_HUMAN (4-256): 1.45e-95: 285: 26.49		P5CR3_HUMAN (2-256): 8.05e-90: 268: 21.21
+	Hs
		687224 P5CR1_HUMAN (4-256): 6.27e-96: 285: 24.25		P5CR3_HUMAN (2-256): 8.05e-90: 268: 21.21
+	Ce
		1094293 Q21544_CAEEL (3-256): 2.05e-90: 270: 21.21		Q21544_CAEEL (3-256): 2.05e-90: 270: 21.21
+	Dm
		1155015 Q6NP47_DROME (2-255): 1.19e-89: 270: 25.64		Q6NP47_DROME (2-255): 1.19e-89: 270: 25.64
+	Hs
		1121399 P5CR3_HUMAN (2-256): 8.05e-90: 268: 21.21		P5CR3_HUMAN (2-256): 8.05e-90: 268: 21.21
+	Mm
		1322177 P5CR3_MOUSE (2-256): 1.37e-89: 268: 20.08		P5CR3_MOUSE (2-256): 1.37e-89: 268: 20.08
+	Dm
		1358492 Q9V3F8_DROME (2-255): 1.05e-89: 268: 25.64		Q9V3F8_DROME (2-255): 1.05e-89: 268: 25.64
+	Dm
		1364710 Q9VEJ3_DROME (3-256): 2.5e-89: 267: 19.47		Q9VEJ3_DROME (3-256): 2.5e-89: 267: 19.47
+	Cj
		1007560 Q0P9H8_CAMJE (3-254): 5.59e-76: 232: 36.22		Q0P9H8_CAMJE (3-254): 5.59e-76: 232: 36.22
+	Sc
		686880 P5CR_YEAST (4-253): 1.11e-68: 215: 23.27		P5CR_YEAST (4-253): 1.11e-68: 215: 23.27
+	Dm
		1213345 Q8IN96_DROME (93-256): 3.19e-61: 192: 19.05		Q8IN96_DROME (93-256): 3.19e-61: 192: 19.05