HitPredict

Interactor 1: KLOT (O35082)
Klotho (EC 3.2.1.31) [Cleaved into: Klotho peptide]
Gene: Kl

Interactor 2: FGFR2 (P21803)
Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (Keratinocyte growth factor receptor) (KGFR) (CD antigen CD332)
Gene: FGFR2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	16436388
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Glyco_hydro_1~I-set
Common GO terms	GO:0005576 - extracellular region GO:0008543 - fibroblast growth factor receptor signaling pathway GO:0017134 - fibroblast growth factor binding
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1014 Mm			1 821
+	Mm
		192157 KLOT_MOUSE (34-1014): 0: 1385: 100.00		FGFR1_MOUSE (1-820): 0: 761: 69.72
+	Hs
		601541 KLOTB_HUMAN (15-1013): 0: 1183: 45.48		FGFR2_HUMAN (1-821): 0: 850: 96.96
+	Hs
		508088 KLOTB_HUMAN (15-1013): 0: 1183: 45.48		FGFR1_HUMAN (1-820): 0: 765: 70.45
+	Mm
		555271 KLOTB_MOUSE (15-1014): 0: 1146: 44.81		FGFR1_MOUSE (1-820): 0: 761: 69.72
+	Mm
		192163 KLOT_MOUSE (34-1014): 0: 1385: 100.00		FGFR4_MOUSE (3-249): 1.22e-20: 99.4: 17.73
+	Mm
		192164 KLOT_MOUSE (34-1014): 0: 1385: 100.00		FGFR3_MOUSE (3-249): 1.94e-20: 99: 17.39
+	Mm
		93854 KLOT_MOUSE (34-1014): 0: 1385: 100.00		E9QNJ9_MOUSE (3-251): 2.29e-19: 95.5: 16.25
+	Hs
		609401 KLOTB_HUMAN (15-1013): 0: 1183: 45.48		FGFR3_HUMAN (3-249): 1.01e-20: 99.8: 16.43
+	Hs
		608033 KLOTB_HUMAN (15-1013): 0: 1183: 45.48		FGFR4_HUMAN (3-249): 5.51e-19: 94: 17.73
+	Mm
		975159 KLOTB_MOUSE (15-1014): 0: 1146: 44.81		FGFR4_MOUSE (3-249): 1.22e-20: 99.4: 17.73
+	Ce
		1014307 Q18758_CAEEL (521-951): 1.56e-143: 439: 25.73		EGL15_CAEEL (17-251): 4.58e-22: 104: 17.29