HitPredict

Interactor 1: SMAD6 (O35182)
Mothers against decapentaplegic homolog 6 (MAD homolog 6) (Mothers against DPP homolog 6) (Mad homolog 7) (SMAD family member 6) (SMAD 6) (Smad6)
Gene: SMAD6

Interactor 2: SMUF1 (Q9CUN6)
E3 ubiquitin-protein ligase SMURF1 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1)
Gene: Smurf1

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.56 0.60 0.584

The method score is based on:

Property Details
Experiments 19561075, 17118358
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005829 - cytosol
GO:0030154 - cell differentiation
GO:0030279 - negative regulation of ossification
GO:0030509 - BMP signaling pathway
GO:0030512 - negative regulation of transforming growth factor beta receptor signaling pathway
and 1 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 495
Mm

1 731
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024