HitPredict - High confidence protein-protein interactions

Interactor 1: TNF11 (O35235)
Tumor necrosis factor ligand superfamily member 11 (Osteoclast differentiation factor) (ODF) (Osteoprotegerin ligand) (OPGL) (Receptor activator of nuclear factor kappa-B ligand) (RANKL) (TNF-related activation-induced cytokine) (TRANCE) (CD antigen CD254) [Cleaved into: Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form]
Gene: Tnfsf11

Interactor 2: TNF11 (O35235)
Tumor necrosis factor ligand superfamily member 11 (Osteoclast differentiation factor) (ODF) (Osteoprotegerin ligand) (OPGL) (Receptor activator of nuclear factor kappa-B ligand) (RANKL) (TNF-related activation-induced cytokine) (TRANCE) (CD antigen CD254) [Cleaved into: Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form]
Gene: Tnfsf11

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	23039992
Identification Methods	molecular sieving
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	TNF~TNF
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0001503 - ossification GO:0002158 - osteoclast proliferation GO:0002548 - monocyte chemotaxis GO:0005125 - cytokine activity and 40 others more... GO:0005164 - tumor necrosis factor receptor binding GO:0005615 - extracellular space GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0006955 - immune response GO:0007254 - JNK cascade GO:0009887 - animal organ morphogenesis GO:0010628 - positive regulation of gene expression GO:0019722 - calcium-mediated signaling GO:0030316 - osteoclast differentiation GO:0032813 - tumor necrosis factor receptor superfamily binding GO:0033209 - tumor necrosis factor-mediated signaling pathway GO:0033598 - mammary gland epithelial cell proliferation GO:0034112 - positive regulation of homotypic cell-cell adhesion GO:0036035 - osteoclast development GO:0038001 - paracrine signaling GO:0042327 - positive regulation of phosphorylation GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0043491 - phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0044691 - tooth eruption GO:0045453 - bone resorption GO:0045670 - regulation of osteoclast differentiation GO:0045672 - positive regulation of osteoclast differentiation GO:0045780 - positive regulation of bone resorption GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0046330 - positive regulation of JNK cascade GO:0048018 - receptor ligand activity GO:0048535 - lymph node development GO:0050870 - positive regulation of T cell activation GO:0051091 - positive regulation of DNA-binding transcription factor activity GO:0051466 - positive regulation of corticotropin-releasing hormone secretion GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0055074 - calcium ion homeostasis GO:0060348 - bone development GO:0060749 - mammary gland alveolus development GO:0070371 - ERK1 and ERK2 cascade GO:0070374 - positive regulation of ERK1 and ERK2 cascade GO:0071812 - positive regulation of fever generation by positive regulation of prostaglandin secretion GO:1990830 - cellular response to leukemia inhibitory factor GO:2001206 - positive regulation of osteoclast development
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1	316
Mm

1	316

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Last updated: 15 Jul 2024