HitPredict

Interactor 1: TNF11 (O35235)
Tumor necrosis factor ligand superfamily member 11 (Osteoclast differentiation factor) (ODF) (Osteoprotegerin ligand) (OPGL) (Receptor activator of nuclear factor kappa-B ligand) (RANKL) (TNF-related activation-induced cytokine) (TRANCE) (CD antigen CD254) [Cleaved into: Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form]
Gene: Tnfsf11

Interactor 2: TNR11 (O35305)
Tumor necrosis factor receptor superfamily member 11A (Osteoclast differentiation factor receptor) (ODFR) (Receptor activator of NF-KB) (CD antigen CD265)
Gene: Tnfrsf11a

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.81 1.00 0.903

The method score is based on:

Property Details
Experiments 36194667, 21059944, 23039992, 10097072
Identification Methods affinity chromatography technology, molecular sieving, isothermal titration calorimetry, surface plasmon resonance, x-ray crystallography, bio-layer interferometry, cross-linking study
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains RANK_CRD_2~TNF, TNF~TNFR_c6
Common GO terms GO:0001503 - ossification
GO:0033209 - tumor necrosis factor-mediated signaling pathway
GO:0045672 - positive regulation of osteoclast differentiation
GO:0045780 - positive regulation of bone resorption
GO:0048535 - lymph node development
and 4 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 316
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024