Interactor 1: FAK1 (O35346)
Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)
Gene: Ptk2

Interactor 2: FAK1 (O35346)
Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)
Gene: Ptk2

Species: Rattus norvegicus

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.74 1.00 0.865

The method score is based on:

Property Details
Experiments 7673154, 24480479
Identification Methods enzymatic study, anti tag coimmunoprecipitation, surface plasmon resonance, cosedimentation in solution, blue native page, molecular sieving, x ray scattering, pull down, isothermal titration calorimetry, protein kinase assay
Interaction Type direct interaction, physical association, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains FERM_M~FERM_M, FERM_M~FERM_N_2, FERM_M~PK_Tyr_Ser-Thr, FERM_N_2~PK_Tyr_Ser-Thr, Focal_AT~Focal_AT, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr
Common GO terms GO:0000165 - MAPK cascade
GO:0000226 - microtubule cytoskeleton organization
GO:0001525 - angiogenesis
GO:0001568 - blood vessel development
GO:0001570 - vasculogenesis
and 99 others

more...

Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1055
Rn

1 1055
+ Hs
+ Mm
+ Gg
+ Rn
+ Hs
+ Hs
+ Hs
+ Mm
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Gg
+ Mm
+ Hs
+ Rn
+ Mm
+ Mm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024