HitPredict

Interactor 1: SEM6A (O35464)
Semaphorin-6A (Semaphorin Q) (Sema Q) (Semaphorin VIA) (Sema VIA) (Semaphorin-6A-1) (SEMA6A-1)
Gene: Sema6a

Interactor 2: PLXA2 (P70207)
Plexin-A2 (Plex 2) (Plexin-2)
Gene: Plxna2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.866

Property	Details
Experiments	26633812, 20881961, 20877282
Identification Methods	pull down, x-ray crystallography, surface plasmon resonance, anti tag coimmunoprecipitation
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PSI~Sema, PSI~TIG, PSI~TIG_2, PSI~TIG_plexin, Sema~Sema, Sema~TIG, Sema~TIG_plexin
Common GO terms	GO:0005886 - plasma membrane GO:0007166 - cell surface receptor signaling pathway GO:0051642 - centrosome localization GO:0071526 - semaphorin-plexin signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1031 Mm			1 1894
+	Mm
		192797 SEM6A_MOUSE (1-1031): 0: 985: 100.00		PLXA4_MOUSE (3-1894): 0: 2509: 66.72
+	Mm
		936310 SEM6D_MOUSE (7-1031): 0: 804: 44.56		PLXA2_MOUSE (1-1894): 0: 2671: 100.00
+	Mm
		192794 SEM6A_MOUSE (1-1031): 0: 985: 100.00		PLXA1_MOUSE (23-1894): 0: 2431: 63.11
+	Mm
		936311 SEM3D_MOUSE (4-654): 0: 664: 27.66		PLXA2_MOUSE (1-1894): 0: 2671: 100.00
+	Mm
		1176226 SEM6D_MOUSE (7-1031): 0: 804: 44.56		PLXA4_MOUSE (3-1894): 0: 2509: 66.72
+	Mm
		222744 SEM6B_MOUSE (2-883): 0: 615: 41.56		PLXA2_MOUSE (1-1894): 0: 2671: 100.00
+	Mm
		936300 SEM6D_MOUSE (7-1031): 0: 804: 44.56		PLXA1_MOUSE (23-1894): 0: 2431: 63.11
+	Mm
		936315 SEM6D_MOUSE (7-1031): 0: 804: 44.56		PLXA3_MOUSE (17-1894): 0: 2429: 59.09
+	Mm
		139669 SEM3A_MOUSE (4-666): 0: 676: 28.38		PLXA4_MOUSE (3-1894): 0: 2509: 66.72
+	Mm
		222745 SEM6B_MOUSE (2-883): 0: 615: 41.56		PLXA4_MOUSE (3-1894): 0: 2509: 66.72
+	Hs
		165243 SEM4C_HUMAN (1-672): 0: 596: 26.44		PLXB2_HUMAN (35-1891): 0: 1936: 32.12
+	Mm
		1112528 SEM3D_MOUSE (4-654): 0: 664: 27.66		PLXD1_MOUSE (45-1891): 0: 1859: 31.35
+	Mm
		71305 SEM4C_MOUSE (1-672): 0: 593: 27.12		PLXB2_MOUSE (35-1891): 0: 1907: 31.94
+	Mm
		936364 SEM3E_MOUSE (14-655): 0: 637: 25.53		PLXD1_MOUSE (45-1891): 0: 1859: 31.35
+	Hs
		165342 SEM3E_HUMAN (14-655): 0: 632: 25.68		PLXD1_HUMAN (45-1891): 0: 1825: 31.32
+	Mm
		1176229 SEM6D_MOUSE (7-1031): 0: 804: 44.56		PLXC1_MOUSE (62-912): 1.17e-100: 360: 17.43
+	Mm
		139662 SEM3A_MOUSE (4-666): 0: 676: 28.38		SEM3A_MOUSE (40-553): 1.23e-126: 419: 14.79
+	Hs
		1055532 SEM3C_HUMAN (2-638): 0: 635: 27.25		SEM3A_HUMAN (40-553): 5.03e-126: 417: 14.97
+	Hs
		303598 SEM3C_HUMAN (2-638): 0: 635: 27.25		SEM3D_HUMAN (41-539): 1.39e-121: 405: 17.66
+	Hs
		1318972 SEM4C_HUMAN (1-672): 0: 596: 26.44		SEM4A_HUMAN (32-595): 4.36e-120: 400: 18.34