HitPredict

Interactor 1: FYB1 (O35601)
FYN-binding protein 1 (Adhesion and degranulation promoting adaptor protein) (ADAP) (FYB-120/130) (p120/p130) (FYN-T-binding protein) (SLAP-130) (SLP-76-associated phosphoprotein)
Gene: FYB1

Interactor 2: GRAP2 (O89100)
GRB2-related adaptor protein 2 (Adapter protein GRID) (GADS protein) (GRB-2-like protein) (GRB2L) (GRB-2-related monocytic adapter protein) (MONA) (Monocytic adapter) (GRBLG) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adaptor protein GrpL)
Gene: GRAP2

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	1.00	0.747

Property	Details
Experiments	12176364
Identification Methods	coimmunoprecipitation, pull down, peptide array
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	SH2~SH3_2, SH3_1~SH3_2
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 819 Mm			1 322
+	Mm
		193089 FYB1_MOUSE (1-819): 2.37e-92: 310: 100.00		LYN_MOUSE (3-136): 1.95e-55: 189: 31.76
+	Hs
		167733 FYB1_HUMAN (1-819): 5.4e-72: 253: 70.40		GRAP2_HUMAN (1-322): 7.19e-63: 204: 72.42
+	Hs
		167735 FYB1_HUMAN (1-819): 5.4e-72: 253: 70.40		ABL1_HUMAN (4-136): 1.18e-50: 182: 35.71
+	Mm
		193090 FYB1_MOUSE (1-819): 2.37e-92: 310: 100.00		FYN_MOUSE (184-320): 1.4e-16: 82.1: 24.82
+	Mm
		193088 FYB1_MOUSE (1-819): 2.37e-92: 310: 100.00		LCK_MOUSE (255-321): 5.44e-10: 62.1: 24.64
+	Hs
		167743 FYB1_HUMAN (1-819): 5.4e-72: 253: 70.40		RASA1_HUMAN (51-147): 7.18e-19: 89.3: 29.13
+	Hs
		167737 FYB1_HUMAN (1-819): 5.4e-72: 253: 70.40		FYN_HUMAN (184-320): 2.22e-16: 81.7: 24.82
+	Hs
		167748 FYB1_HUMAN (1-819): 5.4e-72: 253: 70.40		CRKL_HUMAN (245-322): 7.5e-13: 69.8: 24.05
+	Hs
		167751 FYB1_HUMAN (1-819): 5.4e-72: 253: 70.40		GRB2_HUMAN (3-53): 1.98e-11: 64.6: 30.77
+	Hs
		433701 ANK2_HUMAN (65-703): 2.74e-22: 105: 13.21		LYN_HUMAN (3-136): 6.01e-56: 190: 31.08
+	Hs
		433853 MICA3_HUMAN (3-733): 5.91e-21: 101: 13.15		LYN_HUMAN (3-136): 6.01e-56: 190: 31.08
+	Hs
		297808 K0754_HUMAN (6-528): 3.19e-20: 99: 8.56		LYN_HUMAN (3-136): 6.01e-56: 190: 31.08
+	Hs
		433954 PRAM_HUMAN (16-570): 1.35e-13: 76.7: 11.47		LYN_HUMAN (3-136): 6.01e-56: 190: 31.08
+	Hs
		517796 NFH_HUMAN (154-757): 2.27e-25: 115: 13.74		GRB2_HUMAN (3-53): 1.98e-11: 64.6: 30.77
+	Hs
		1056926 MDC1_HUMAN (59-779): 6.48e-24: 110: 9.90		SH3K1_HUMAN (3-61): 7.41e-11: 65: 27.42
+	Hs
		924484 ANK2_HUMAN (65-703): 2.74e-22: 105: 13.21		GRB2_HUMAN (3-53): 1.98e-11: 64.6: 30.77
+	Hs
		203191 SYNJ1_HUMAN (273-667): 1.53e-10: 67.4: 8.27		VINEX_HUMAN (33-320): 1.64e-17: 85: 14.33
+	Hs
		1191857 PRAM_HUMAN (16-570): 1.35e-13: 76.7: 11.47		SH3R1_HUMAN (37-320): 3.44e-13: 72.3: 11.54
+	Hs
		924760 PRG4_HUMAN (22-455): 3.68e-14: 79: 11.24		GRB2_HUMAN (3-53): 1.98e-11: 64.6: 30.77
+	Hs
		203198 SYNJ1_HUMAN (273-667): 1.53e-10: 67.4: 8.27		LCK_HUMAN (255-321): 4.38e-10: 62.5: 24.64