HitPredict

Interactor 1: MDM4 (O35618)
Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4)
Gene: MDM4

Interactor 2: MDM2 (P23804)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.91 1.00 0.958

The method score is based on:

Property Details
Experiments 19573810, 25981963, 20697359, 21730132, 22666487, 17616658, 25117711
Identification Methods affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains SWIB~SWIB, zf-C3HC4_3~zf-C3HC4_3
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0002027 - regulation of heart rate
GO:0003170 - heart valve development
GO:0003181 - atrioventricular valve morphogenesis
GO:0003203 - endocardial cushion morphogenesis
and 6 others

more...
Homologous interactions 5

Homologous interactions

Color coding for hit scores

1 489
Mm

1 489
+ Hs
+ Hs
+ Mm
+ Hs
+ Dr

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024