HitPredict

Interactor 1: SOCS1 (O35716)
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1)
Gene: SOCS1

Interactor 2: KIT (P05532)
Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
Gene: KIT

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.814

Property	Details
Experiments	10679268, 10022833, 14707129
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0019221 - cytokine-mediated signaling pathway GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 212 Mm			1 979
+	Mm
		403545 SOCS6_MOUSE (67-210): 8.8e-40: 144: 26.06		KIT_MOUSE (1-979): 0: 823: 96.85
+	Hs
		499278 SOCS4_HUMAN (13-211): 6.4e-45: 156: 19.81		KIT_HUMAN (1-978): 0: 795: 79.55
+	Hs
		181778 SOCS1_HUMAN (1-212): 2.59e-45: 151: 94.81		KIT_HUMAN (1-978): 0: 795: 79.55
+	Hs
		208982 NCK2_HUMAN (2-176): 2.33e-43: 151: 18.64		KIT_HUMAN (1-978): 0: 795: 79.55
+	Hs
		256847 SOCS5_HUMAN (8-211): 1.48e-41: 149: 19.81		KIT_HUMAN (1-978): 0: 795: 79.55
+	Hs
		147381 SOCS3_HUMAN (40-208): 2.32e-42: 144: 27.27		KIT_HUMAN (1-978): 0: 795: 79.55
+	Mm
		193337 SOCS1_MOUSE (1-212): 3.72e-50: 163: 100.00		CSF1R_MOUSE (34-935): 0: 649: 37.84
+	Hs
		208979 NCK2_HUMAN (2-176): 2.33e-43: 151: 18.64		PGFRB_HUMAN (30-974): 0: 607: 30.29
+	Hs
		452344 NCK1_HUMAN (4-175): 1.37e-40: 143: 18.39		PGFRB_HUMAN (30-974): 0: 607: 30.29
+	Hs
		181810 SOCS1_HUMAN (1-212): 2.59e-45: 151: 94.81		FLT3_HUMAN (14-976): 3.65e-177: 543: 30.41
+	Mm
		959810 SOCS6_MOUSE (67-210): 8.8e-40: 144: 26.06		FLT3_MOUSE (10-977): 4.33e-177: 543: 29.69
+	Hs
		209063 NCK2_HUMAN (2-176): 2.33e-43: 151: 18.64		NTRK3_HUMAN (283-927): 7.67e-132: 420: 20.66
+	Hs
		208976 NCK2_HUMAN (2-176): 2.33e-43: 151: 18.64		RET_HUMAN (570-947): 8.53e-74: 266: 39.68
+	Hs
		434130 NCK1_HUMAN (4-175): 1.37e-40: 143: 18.39		RET_HUMAN (570-947): 8.53e-74: 266: 39.68
+	Hs
		181796 SOCS1_HUMAN (1-212): 2.59e-45: 151: 94.81		FGFR3_HUMAN (3-312): 3.93e-54: 205: 14.72
+	Hs
		208983 NCK2_HUMAN (2-176): 2.33e-43: 151: 18.64		FGFR1_HUMAN (8-326): 2.76e-53: 202: 15.16
+	Hs
		147391 SOCS3_HUMAN (40-208): 2.32e-42: 144: 27.27		FGFR3_HUMAN (3-312): 3.93e-54: 205: 14.72
+	Hs
		208993 NCK2_HUMAN (2-176): 2.33e-43: 151: 18.64		FGFR4_HUMAN (22-322): 8.7e-42: 167: 12.36
+	Hs
		181766 SOCS1_HUMAN (1-212): 2.59e-45: 151: 94.81		CSF1R_HUMAN (9-322): 2.32e-14: 79.8: 13.80
+	Hs
		147375 SOCS3_HUMAN (40-208): 2.32e-42: 144: 27.27		CSF1R_HUMAN (9-322): 2.32e-14: 79.8: 13.80